FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3015086054> ?p ?o ?g. }

• W3015086054 endingPage "3648" @default.
• W3015086054 startingPage "3641" @default.
• W3015086054 abstract "Pancreatic ductal adenocarcinoma (PDAC) is a lethal disease with dismal survival rates. Tumor microenvironment (TME), comprising of immune cells and cancer-associated fibroblasts, plays a key role in driving poor prognosis and resistance to chemotherapy. Herein, we aimed to identify a TME-associated, risk-stratification gene biomarker signature in PDAC.The initial biomarker discovery was performed in The Cancer Genome Atlas (TCGA, n = 163) transcriptomic data. This was followed by independent validation of the gene signature in the International Cancer Genome Consortium (ICGC, n = 95), E-MTAB-6134 (n = 288), and GSE71729 (n = 123) datasets for predicting overall survival (OS), and for its ability to detect poor molecular subtypes. Clinical validation and nomogram establishment was undertaken by performing multivariate Cox regression analysis.Our biomarker discovery effort identified a 15-gene immune, stromal, and proliferation (ISP) gene signature that significantly associated with poor OS [HR, 3.90; 95% confidence interval (CI), 2.36-6.41; P < 0.0001]. This signature also robustly predicted survival in three independent validation cohorts ICGC [HR, 2.63 (1.56-4.41); P < 0.0001], E-MTAB-6134 [HR, 1.53 (1.14-2.04); P = 0.004], and GSE71729 [HR, 2.33 (1.49-3.63); P < 0.0001]. Interestingly, the ISP signature also permitted identification of poor molecular PDAC subtypes with excellent accuracy in all four cohorts; TCGA (AUC = 0.94), ICGC (AUC = 0.91), E-MTAB-6134 (AUC = 0.80), and GSE71729 (AUC = 0.83). The ISP-derived high-risk patients exhibited significantly poor OS in a clinical validation cohort [n = 119; HR, 2.62 (1.50-4.56); P = 0.0004]. A nomogram was established which included the ISP, CA19-9, and T- and N-stage for eventual clinical translation.We report a novel gene signature for risk-stratification and robust identification of patients with PDAC with poor molecular subtypes." @default.
• W3015086054 created "2020-04-10" @default.
• W3015086054 creator A5010927861 @default.
• W3015086054 creator A5018770643 @default.
• W3015086054 creator A5019126958 @default.
• W3015086054 creator A5019440060 @default.
• W3015086054 creator A5058068325 @default.
• W3015086054 creator A5066425406 @default.
• W3015086054 creator A5068838933 @default.
• W3015086054 date "2020-07-15" @default.
• W3015086054 modified "2023-10-15" @default.
• W3015086054 title "A 15-Gene Immune, Stromal, and Proliferation Gene Signature that Significantly Associates with Poor Survival in Patients with Pancreatic Ductal Adenocarcinoma" @default.
• W3015086054 cites W1497915798 @default.
• W3015086054 cites W1499730823 @default.
• W3015086054 cites W1931508686 @default.
• W3015086054 cites W2012532871 @default.
• W3015086054 cites W2014067939 @default.
• W3015086054 cites W2028433016 @default.
• W3015086054 cites W2060324950 @default.
• W3015086054 cites W2065215232 @default.
• W3015086054 cites W2086834665 @default.
• W3015086054 cites W2137217704 @default.
• W3015086054 cites W2149199519 @default.
• W3015086054 cites W2151253787 @default.
• W3015086054 cites W2154790710 @default.
• W3015086054 cites W2158134441 @default.
• W3015086054 cites W2164286021 @default.
• W3015086054 cites W2165480504 @default.
• W3015086054 cites W2285093314 @default.
• W3015086054 cites W2518249323 @default.
• W3015086054 cites W2579046240 @default.
• W3015086054 cites W2586537166 @default.
• W3015086054 cites W2592137794 @default.
• W3015086054 cites W2594738913 @default.
• W3015086054 cites W2778853355 @default.
• W3015086054 cites W2781642641 @default.
• W3015086054 cites W2788455546 @default.
• W3015086054 cites W2789423629 @default.
• W3015086054 cites W2803164733 @default.
• W3015086054 cites W2808272780 @default.
• W3015086054 cites W2889433609 @default.
• W3015086054 cites W2898435366 @default.
• W3015086054 cites W2911188335 @default.
• W3015086054 doi "https://doi.org/10.1158/1078-0432.ccr-19-4044" @default.
• W3015086054 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7367725" @default.
• W3015086054 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32234757" @default.
• W3015086054 hasPublicationYear "2020" @default.
• W3015086054 type Work @default.
• W3015086054 sameAs 3015086054 @default.
• W3015086054 citedByCount "38" @default.
• W3015086054 countsByYear W30150860542020 @default.
• W3015086054 countsByYear W30150860542021 @default.
• W3015086054 countsByYear W30150860542022 @default.
• W3015086054 countsByYear W30150860542023 @default.
• W3015086054 crossrefType "journal-article" @default.
• W3015086054 hasAuthorship W3015086054A5010927861 @default.
• W3015086054 hasAuthorship W3015086054A5018770643 @default.
• W3015086054 hasAuthorship W3015086054A5019126958 @default.
• W3015086054 hasAuthorship W3015086054A5019440060 @default.
• W3015086054 hasAuthorship W3015086054A5058068325 @default.
• W3015086054 hasAuthorship W3015086054A5066425406 @default.
• W3015086054 hasAuthorship W3015086054A5068838933 @default.
• W3015086054 hasBestOaLocation W30150860541 @default.
• W3015086054 hasConcept C104317684 @default.
• W3015086054 hasConcept C121608353 @default.
• W3015086054 hasConcept C124535831 @default.
• W3015086054 hasConcept C126322002 @default.
• W3015086054 hasConcept C143998085 @default.
• W3015086054 hasConcept C150194340 @default.
• W3015086054 hasConcept C16930146 @default.
• W3015086054 hasConcept C203014093 @default.
• W3015086054 hasConcept C2779733811 @default.
• W3015086054 hasConcept C2780210213 @default.
• W3015086054 hasConcept C2781182431 @default.
• W3015086054 hasConcept C2781197716 @default.
• W3015086054 hasConcept C34626388 @default.
• W3015086054 hasConcept C46111723 @default.
• W3015086054 hasConcept C502942594 @default.
• W3015086054 hasConcept C50382708 @default.
• W3015086054 hasConcept C54355233 @default.
• W3015086054 hasConcept C71924100 @default.
• W3015086054 hasConcept C86803240 @default.
• W3015086054 hasConcept C8891405 @default.
• W3015086054 hasConceptScore W3015086054C104317684 @default.
• W3015086054 hasConceptScore W3015086054C121608353 @default.
• W3015086054 hasConceptScore W3015086054C124535831 @default.
• W3015086054 hasConceptScore W3015086054C126322002 @default.
• W3015086054 hasConceptScore W3015086054C143998085 @default.
• W3015086054 hasConceptScore W3015086054C150194340 @default.
• W3015086054 hasConceptScore W3015086054C16930146 @default.
• W3015086054 hasConceptScore W3015086054C203014093 @default.
• W3015086054 hasConceptScore W3015086054C2779733811 @default.
• W3015086054 hasConceptScore W3015086054C2780210213 @default.
• W3015086054 hasConceptScore W3015086054C2781182431 @default.
• W3015086054 hasConceptScore W3015086054C2781197716 @default.
• W3015086054 hasConceptScore W3015086054C34626388 @default.
• W3015086054 hasConceptScore W3015086054C46111723 @default.
• W3015086054 hasConceptScore W3015086054C502942594 @default.

• next