FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3015104756> ?p ?o ?g. }

• W3015104756 endingPage "101702" @default.
• W3015104756 startingPage "101702" @default.
• W3015104756 abstract "This investigation aimed to eliminate the residual organic solvent dichloromethane (DCM) from microspheres containing risperidone using supercritical carbon dioxide (scCO2). A conventional emulsion-solvent evaporation procedure was used to prepare the microspheres, and scCO2 eliminated the residual DCM. To obtain the maximum elimination yield %, central composite design (CCD) with the parameters of static time, dynamic time, pressure, and temperature was applied. After scCO2 treatment, the residual DCM was analyzed using headspace GC-FID. Finally, the characterization, encapsulation efficiency, drug loading, and in-vitro release of the microspheres were also investigated. For maximum elimination % of residual DCM using scCO2 (99.43%), the static time, dynamic time, pressure, and temperature were 21.31 min, 119.17 min, 226.44 bar, and 44.77 °C, respectively. DCM contents of the risperidone-PLGA microspheres before and after scCO2 treatment were 4612 ± 198 μg/mL and <21.93 μg/mL, respectively. The mean particle sizes, pore diameter, and porosity after scCO2 treatment were higher than the pre-treatment values. ScCO2 technology could increase both porosity and DCM removal, which enhances the uniform distribution of the drug in the matrix. The microspheres before scCO2 treatment contains larger amounts of solvents, which could enhance polymeric chain mobility and thus drug release. Consequently, it leads to the sustained release of the drug from the microsphere matrix." @default.
• W3015104756 created "2020-04-10" @default.
• W3015104756 creator A5038004542 @default.
• W3015104756 creator A5056193314 @default.
• W3015104756 creator A5068435169 @default.
• W3015104756 creator A5074807523 @default.
• W3015104756 creator A5080076536 @default.
• W3015104756 creator A5083715779 @default.
• W3015104756 date "2020-06-01" @default.
• W3015104756 modified "2023-09-27" @default.
• W3015104756 title "Elimination of residual solvent from PLGA microspheres containing risperidone using supercritical carbon dioxide" @default.
• W3015104756 cites W117436169 @default.
• W3015104756 cites W1968396250 @default.
• W3015104756 cites W1972852190 @default.
• W3015104756 cites W1991913551 @default.
• W3015104756 cites W1992342663 @default.
• W3015104756 cites W1992445150 @default.
• W3015104756 cites W2016111162 @default.
• W3015104756 cites W2027865819 @default.
• W3015104756 cites W2046627126 @default.
• W3015104756 cites W2058464257 @default.
• W3015104756 cites W2075385589 @default.
• W3015104756 cites W2077214864 @default.
• W3015104756 cites W2082334851 @default.
• W3015104756 cites W2112499442 @default.
• W3015104756 cites W2131290715 @default.
• W3015104756 cites W2135323071 @default.
• W3015104756 cites W2172236423 @default.
• W3015104756 cites W2281263790 @default.
• W3015104756 cites W2563202234 @default.
• W3015104756 cites W2580190480 @default.
• W3015104756 cites W2587496697 @default.
• W3015104756 cites W2604595565 @default.
• W3015104756 cites W2781039819 @default.
• W3015104756 cites W2892547278 @default.
• W3015104756 cites W2900317750 @default.
• W3015104756 cites W2902330596 @default.
• W3015104756 cites W2912118776 @default.
• W3015104756 cites W2912570183 @default.
• W3015104756 cites W2924360968 @default.
• W3015104756 cites W2959537767 @default.
• W3015104756 cites W2964362438 @default.
• W3015104756 cites W2988233645 @default.
• W3015104756 cites W2993989155 @default.
• W3015104756 doi "https://doi.org/10.1016/j.jddst.2020.101702" @default.
• W3015104756 hasPublicationYear "2020" @default.
• W3015104756 type Work @default.
• W3015104756 sameAs 3015104756 @default.
• W3015104756 citedByCount "10" @default.
• W3015104756 countsByYear W30151047562021 @default.
• W3015104756 countsByYear W30151047562022 @default.
• W3015104756 countsByYear W30151047562023 @default.
• W3015104756 crossrefType "journal-article" @default.
• W3015104756 hasAuthorship W3015104756A5038004542 @default.
• W3015104756 hasAuthorship W3015104756A5056193314 @default.
• W3015104756 hasAuthorship W3015104756A5068435169 @default.
• W3015104756 hasAuthorship W3015104756A5074807523 @default.
• W3015104756 hasAuthorship W3015104756A5080076536 @default.
• W3015104756 hasAuthorship W3015104756A5083715779 @default.
• W3015104756 hasConcept C118419359 @default.
• W3015104756 hasConcept C127413603 @default.
• W3015104756 hasConcept C134458231 @default.
• W3015104756 hasConcept C155672457 @default.
• W3015104756 hasConcept C159985019 @default.
• W3015104756 hasConcept C171250308 @default.
• W3015104756 hasConcept C178790620 @default.
• W3015104756 hasConcept C185592680 @default.
• W3015104756 hasConcept C187530423 @default.
• W3015104756 hasConcept C189942447 @default.
• W3015104756 hasConcept C192562407 @default.
• W3015104756 hasConcept C2778123984 @default.
• W3015104756 hasConcept C2780165375 @default.
• W3015104756 hasConcept C2780400988 @default.
• W3015104756 hasConcept C2780471494 @default.
• W3015104756 hasConcept C42360764 @default.
• W3015104756 hasConcept C43617362 @default.
• W3015104756 hasConcept C6648577 @default.
• W3015104756 hasConceptScore W3015104756C118419359 @default.
• W3015104756 hasConceptScore W3015104756C127413603 @default.
• W3015104756 hasConceptScore W3015104756C134458231 @default.
• W3015104756 hasConceptScore W3015104756C155672457 @default.
• W3015104756 hasConceptScore W3015104756C159985019 @default.
• W3015104756 hasConceptScore W3015104756C171250308 @default.
• W3015104756 hasConceptScore W3015104756C178790620 @default.
• W3015104756 hasConceptScore W3015104756C185592680 @default.
• W3015104756 hasConceptScore W3015104756C187530423 @default.
• W3015104756 hasConceptScore W3015104756C189942447 @default.
• W3015104756 hasConceptScore W3015104756C192562407 @default.
• W3015104756 hasConceptScore W3015104756C2778123984 @default.
• W3015104756 hasConceptScore W3015104756C2780165375 @default.
• W3015104756 hasConceptScore W3015104756C2780400988 @default.
• W3015104756 hasConceptScore W3015104756C2780471494 @default.
• W3015104756 hasConceptScore W3015104756C42360764 @default.
• W3015104756 hasConceptScore W3015104756C43617362 @default.
• W3015104756 hasConceptScore W3015104756C6648577 @default.
• W3015104756 hasFunder F4320322855 @default.
• W3015104756 hasLocation W30151047561 @default.
• W3015104756 hasOpenAccess W3015104756 @default.

• next