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• W3015142511 abstract "Abstract It has recently been shown that the loss of the Hippo signaling effectors Yes-associated protein (YAP) and transcriptional coactivator with PDZ-binding motif (TAZ) in adrenocortical steroidogenic cells impairs the postnatal maintenance of the adrenal gland. To further explore the role of Hippo signaling in mouse adrenocortical cells, we conditionally deleted the key Hippo kinases large tumor suppressor homolog kinases 1 and -2 (Lats1 and Lats2, two kinases that antagonize YAP and TAZ transcriptional co-regulatory activity) in steroidogenic cells using an Nr5a1-cre strain (Lats1flox/flox;Lats2flox/flox;Nr5a1-cre). We report here that developing adrenocortical cells adopt characteristics of myofibroblasts in both male and female Lats1flox/flox;Lats2flox/flox;Nr5a1-cre mice, resulting in a loss of steroidogenic gene expression, adrenal failure and death by 2 to 3 weeks of age. A marked accumulation of YAP and TAZ in the nuclei of the myofibroblast-like cell population with an accompanying increase in the expression of their transcriptional target genes in the adrenal glands of Lats1flox/flox;Lats2flox/flox;Nr5a1-cre animals suggested that the myofibroblastic differentiation could be attributed in part to YAP and TAZ. Taken together, our results suggest that Hippo signaling is required to maintain proper adrenocortical cell differentiation and suppresses their differentiation into myofibroblast-like cells." @default.
• W3015142511 created "2020-04-10" @default.
• W3015142511 creator A5000121479 @default.
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• W3015142511 creator A5087380286 @default.
• W3015142511 date "2020-04-02" @default.
• W3015142511 modified "2023-10-18" @default.
• W3015142511 title "Targeted Disruption of <i>Lats1</i> and <i>Lats2</i> in Mice Impairs Adrenal Cortex Development and Alters Adrenocortical Cell Fate" @default.
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• W3015142511 doi "https://doi.org/10.1210/endocr/bqaa052" @default.
• W3015142511 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7211035" @default.
• W3015142511 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32243503" @default.
• W3015142511 hasPublicationYear "2020" @default.
• W3015142511 type Work @default.
• W3015142511 sameAs 3015142511 @default.

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