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- W3015173977 startingPage "106324" @default.
- W3015173977 abstract "Widespread structural and functional brain network changes have been shown in Juvenile Myoclonic Epilepsy (JME) despite normal clinical neuroimaging. We sought to better define these changes using magnetoencephalography (MEG) and source space connectivity analysis for optimal neurophysiological and anatomical localisation. We consecutively recruited 26 patients with JME who underwent resting state MEG recording, along with 26 age-and-sex matched controls. Whole brain connectivity was determined through correlation of Automated Anatomical Labelling (AAL) atlas source space MEG timeseries in conventional frequency bands of interest delta (1−4 Hz), theta (4−8 Hz), alpha (8−13 Hz), beta (13−30 Hz) and gamma (40−60 Hz). We used a Linearly Constrained Minimum Variance (LCMV) beamformer to extract voxel wise time series of ‘virtual sensors’ for the desired frequency bands, followed by connectivity analysis using correlation between frequency- and node-specific power fluctuations, for the voxel maxima in each AAL atlas label, correcting for noise, potentially spurious connections and multiple comparisons. We found increased connectivity in the theta band in posterior brain regions, surviving statistical correction for multiple comparisons (corrected p < 0.05), and decreased connectivity in the beta band in sensorimotor cortex, between right pre- and post- central gyrus (p < 0.05) in JME compared to controls. Altered resting-state MEG connectivity in JME comprised increased connectivity in posterior theta – the frequency band associated with long range connections affecting attention and arousal - and decreased beta-band sensorimotor connectivity. These findings likely relate to altered regulation of the sensorimotor network and seizure prone states in JME." @default.
- W3015173977 created "2020-04-10" @default.
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- W3015173977 date "2020-07-01" @default.
- W3015173977 modified "2023-09-27" @default.
- W3015173977 title "Juvenile myoclonic epilepsy shows increased posterior theta, and reduced sensorimotor beta resting connectivity" @default.
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- W3015173977 doi "https://doi.org/10.1016/j.eplepsyres.2020.106324" @default.
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