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- W3015194282 endingPage "230" @default.
- W3015194282 startingPage "214" @default.
- W3015194282 abstract ": Drug discovery in the scope of cancer therapy has been focused on conventional agents that nonselectively induce DNA damage or selectively inhibit the activity of key oncogenic molecules without affecting their protein levels. An emerging therapeutic strategy that garnered attention in recent years is the induction of Targeted Protein Degradation (TPD) of cellular targets by hijacking the intracellular proteolysis machinery. This novel approach offers several advantages over conventional inhibitors and introduces a paradigm shift in several pharmacological aspects of drug therapy. While TPD has been found to be the major mode of action of clinically approved anticancer agents such as fulvestrant and thalidomide, recent years have witnessed systematic endeavors to expand the repertoire of proteins amenable to therapeutic ablation by TPD. Such endeavors have led to three major classes of agents that induce protein degradation, including molecular glues, Proteolysis Targeting Chimeras (PROTACs) and Hydrophobic Tag (HyT)-based degraders. Here, we briefly highlight agents in these classes and key advances made in the field with a focus on clinical translation in cancer therapy." @default.
- W3015194282 created "2020-04-17" @default.
- W3015194282 creator A5088515206 @default.
- W3015194282 date "2020-12-31" @default.
- W3015194282 modified "2023-10-16" @default.
- W3015194282 title "Targeted Protein Degradation: An Emerging Therapeutic Strategy in Cancer" @default.
- W3015194282 cites W1488181101 @default.
- W3015194282 cites W1512690422 @default.
- W3015194282 cites W1527383154 @default.
- W3015194282 cites W1565539350 @default.
- W3015194282 cites W1597238753 @default.
- W3015194282 cites W1923567272 @default.
- W3015194282 cites W1963673356 @default.
- W3015194282 cites W1973999018 @default.
- W3015194282 cites W1979413406 @default.
- W3015194282 cites W1982166691 @default.
- W3015194282 cites W1983492903 @default.
- W3015194282 cites W1997952190 @default.
- W3015194282 cites W1998384592 @default.
- W3015194282 cites W1998944024 @default.
- W3015194282 cites W1999353132 @default.
- W3015194282 cites W2003872705 @default.
- W3015194282 cites W2008324827 @default.
- W3015194282 cites W2015345028 @default.
- W3015194282 cites W2020031294 @default.
- W3015194282 cites W2023586989 @default.
- W3015194282 cites W2024483482 @default.
- W3015194282 cites W2043526119 @default.
- W3015194282 cites W2044433401 @default.
- W3015194282 cites W2045109197 @default.
- W3015194282 cites W2048964430 @default.
- W3015194282 cites W2051237324 @default.
- W3015194282 cites W2052268618 @default.
- W3015194282 cites W2057272791 @default.
- W3015194282 cites W2062817904 @default.
- W3015194282 cites W2064402334 @default.
- W3015194282 cites W2066713758 @default.
- W3015194282 cites W2068351024 @default.
- W3015194282 cites W2068412287 @default.
- W3015194282 cites W2075394133 @default.
- W3015194282 cites W2076194625 @default.
- W3015194282 cites W2077813812 @default.
- W3015194282 cites W2083469632 @default.
- W3015194282 cites W2086373053 @default.
- W3015194282 cites W2091250038 @default.
- W3015194282 cites W2098002594 @default.
- W3015194282 cites W2109541969 @default.
- W3015194282 cites W2117170436 @default.
- W3015194282 cites W2117692326 @default.
- W3015194282 cites W2124361787 @default.
- W3015194282 cites W2126959871 @default.
- W3015194282 cites W2128903704 @default.
- W3015194282 cites W2136541422 @default.
- W3015194282 cites W2148307287 @default.
- W3015194282 cites W2151683271 @default.
- W3015194282 cites W2157791814 @default.
- W3015194282 cites W2161413435 @default.
- W3015194282 cites W2184668473 @default.
- W3015194282 cites W2243467818 @default.
- W3015194282 cites W2283442479 @default.
- W3015194282 cites W2316160054 @default.
- W3015194282 cites W2323968754 @default.
- W3015194282 cites W2332737325 @default.
- W3015194282 cites W2395038895 @default.
- W3015194282 cites W2409568753 @default.
- W3015194282 cites W2468302041 @default.
- W3015194282 cites W2470671857 @default.
- W3015194282 cites W2530302741 @default.
- W3015194282 cites W2553908226 @default.
- W3015194282 cites W2559947248 @default.
- W3015194282 cites W2561774520 @default.
- W3015194282 cites W2563465351 @default.
- W3015194282 cites W2564891497 @default.
- W3015194282 cites W2580091136 @default.
- W3015194282 cites W2585495993 @default.
- W3015194282 cites W2589026097 @default.
- W3015194282 cites W2589078946 @default.
- W3015194282 cites W2596064219 @default.
- W3015194282 cites W2596306432 @default.
- W3015194282 cites W2604040637 @default.
- W3015194282 cites W2606131188 @default.
- W3015194282 cites W2607978828 @default.
- W3015194282 cites W2611953519 @default.
- W3015194282 cites W2615994102 @default.
- W3015194282 cites W2622721717 @default.
- W3015194282 cites W2704517448 @default.
- W3015194282 cites W2732893177 @default.
- W3015194282 cites W2733066269 @default.
- W3015194282 cites W2743800043 @default.
- W3015194282 cites W2766431227 @default.
- W3015194282 cites W2767332403 @default.
- W3015194282 cites W2777085303 @default.
- W3015194282 cites W2779743226 @default.
- W3015194282 cites W2781383440 @default.
- W3015194282 cites W2783151804 @default.
- W3015194282 cites W2783520674 @default.
- W3015194282 cites W2791182171 @default.
- W3015194282 cites W2791894234 @default.