FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3015197613> ?p ?o ?g. }

• W3015197613 endingPage "1142" @default.
• W3015197613 startingPage "1127" @default.
• W3015197613 abstract "Chronic disability in multiple sclerosis is linked to neuroaxonal degeneration. 4-aminopyridine (4-AP) is used and licensed as a symptomatic treatment to ameliorate ambulatory disability in multiple sclerosis. The presumed mode of action is via blockade of axonal voltage gated potassium channels, thereby enhancing conduction in demyelinated axons. In this study, we provide evidence that in addition to those symptomatic effects, 4-AP can prevent neuroaxonal loss in the CNS. Using in vivo optical coherence tomography imaging, visual function testing and histologic assessment, we observed a reduction in retinal neurodegeneration with 4-AP in models of experimental optic neuritis and optic nerve crush. These effects were not related to an anti-inflammatory mode of action or a direct impact on retinal ganglion cells. Rather, histology and in vitro experiments indicated 4-AP stabilization of myelin and oligodendrocyte precursor cells associated with increased nuclear translocation of the nuclear factor of activated T cells. In experimental optic neuritis, 4-AP potentiated the effects of immunomodulatory treatment with fingolimod. As extended release 4-AP is already licensed for symptomatic multiple sclerosis treatment, we performed a retrospective, multicentre optical coherence tomography study to longitudinally compare retinal neurodegeneration between 52 patients on continuous 4-AP therapy and 51 matched controls. In line with the experimental data, during concurrent 4-AP therapy, degeneration of the macular retinal nerve fibre layer was reduced over 2 years. These results indicate disease-modifying effects of 4-AP beyond symptomatic therapy and provide support for the design of a prospective clinical study using visual function and retinal structure as outcome parameters." @default.
• W3015197613 created "2020-04-17" @default.
• W3015197613 creator A5002625341 @default.
• W3015197613 creator A5007218680 @default.
• W3015197613 creator A5012009103 @default.
• W3015197613 creator A5012275404 @default.
• W3015197613 creator A5012449119 @default.
• W3015197613 creator A5020456692 @default.
• W3015197613 creator A5022410950 @default.
• W3015197613 creator A5022782553 @default.
• W3015197613 creator A5023240220 @default.
• W3015197613 creator A5023912131 @default.
• W3015197613 creator A5024235763 @default.
• W3015197613 creator A5026098505 @default.
• W3015197613 creator A5026760406 @default.
• W3015197613 creator A5028035051 @default.
• W3015197613 creator A5038398867 @default.
• W3015197613 creator A5046354840 @default.
• W3015197613 creator A5047859644 @default.
• W3015197613 creator A5048371879 @default.
• W3015197613 creator A5048881912 @default.
• W3015197613 creator A5052025260 @default.
• W3015197613 creator A5052848358 @default.
• W3015197613 creator A5053411191 @default.
• W3015197613 creator A5056912783 @default.
• W3015197613 creator A5061715150 @default.
• W3015197613 creator A5061851273 @default.
• W3015197613 creator A5062004838 @default.
• W3015197613 creator A5062456050 @default.
• W3015197613 creator A5062578158 @default.
• W3015197613 creator A5065023523 @default.
• W3015197613 creator A5065807251 @default.
• W3015197613 creator A5067928852 @default.
• W3015197613 creator A5071972650 @default.
• W3015197613 creator A5074759103 @default.
• W3015197613 creator A5077603725 @default.
• W3015197613 creator A5078265827 @default.
• W3015197613 creator A5080240992 @default.
• W3015197613 creator A5080245206 @default.
• W3015197613 creator A5086990883 @default.
• W3015197613 creator A5088168545 @default.
• W3015197613 creator A5090006269 @default.
• W3015197613 date "2020-04-01" @default.
• W3015197613 modified "2023-10-07" @default.
• W3015197613 title "Protective effects of 4-aminopyridine in experimental optic neuritis and multiple sclerosis" @default.
• W3015197613 cites W1487447554 @default.
• W3015197613 cites W1551079907 @default.
• W3015197613 cites W1964502095 @default.
• W3015197613 cites W1983444691 @default.
• W3015197613 cites W2001177622 @default.
• W3015197613 cites W2015050903 @default.
• W3015197613 cites W2019547077 @default.
• W3015197613 cites W2031001241 @default.
• W3015197613 cites W2038651295 @default.
• W3015197613 cites W2043906459 @default.
• W3015197613 cites W2044022880 @default.
• W3015197613 cites W2048960037 @default.
• W3015197613 cites W2055820698 @default.
• W3015197613 cites W2060029300 @default.
• W3015197613 cites W2063980734 @default.
• W3015197613 cites W2075584671 @default.
• W3015197613 cites W2101679513 @default.
• W3015197613 cites W2102478723 @default.
• W3015197613 cites W2108333597 @default.
• W3015197613 cites W2122545833 @default.
• W3015197613 cites W2128707151 @default.
• W3015197613 cites W2137424771 @default.
• W3015197613 cites W2138123632 @default.
• W3015197613 cites W2145583517 @default.
• W3015197613 cites W2155680556 @default.
• W3015197613 cites W2157973267 @default.
• W3015197613 cites W2168013023 @default.
• W3015197613 cites W2401147790 @default.
• W3015197613 cites W2548283306 @default.
• W3015197613 cites W2549310065 @default.
• W3015197613 cites W2558260411 @default.
• W3015197613 cites W2566847813 @default.
• W3015197613 cites W2623682056 @default.
• W3015197613 cites W2625158434 @default.
• W3015197613 cites W2765260668 @default.
• W3015197613 cites W2767711191 @default.
• W3015197613 cites W2788103288 @default.
• W3015197613 cites W2797557958 @default.
• W3015197613 cites W2807226597 @default.
• W3015197613 cites W2841591265 @default.
• W3015197613 cites W2886235504 @default.
• W3015197613 cites W2901826394 @default.
• W3015197613 cites W4253381763 @default.
• W3015197613 doi "https://doi.org/10.1093/brain/awaa062" @default.
• W3015197613 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32293668" @default.
• W3015197613 hasPublicationYear "2020" @default.
• W3015197613 type Work @default.
• W3015197613 sameAs 3015197613 @default.
• W3015197613 citedByCount "25" @default.
• W3015197613 countsByYear W30151976132020 @default.
• W3015197613 countsByYear W30151976132021 @default.
• W3015197613 countsByYear W30151976132022 @default.
• W3015197613 countsByYear W30151976132023 @default.

• next