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- W3015233485 abstract "Chemoimmunotherapy is the standard frontline treatment for symptomatic or high tumor burden follicular lymphoma. Better understanding of the molecular mechanisms of lymphomagenesis has led to the development of drugs targeting these pathways. The phosphatidylinositol-3-kinase pathway is an important signaling pathway in B-cell lymphomas. Three drugs in this class have received FDA approval. We describe the efficacy and toxicities of phosphatidylinositol-3-kinase inhibitors. Response rates in highly refractory disease are high, demonstrate few long-term remissions, and have high long-term toxicity. Early data on dosing and combination strategies are promising and may change how we use these agents in the coming years." @default.
- W3015233485 created "2020-04-17" @default.
- W3015233485 creator A5004025497 @default.
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- W3015233485 date "2020-08-01" @default.
- W3015233485 modified "2023-10-04" @default.
- W3015233485 title "Phosphatidylinositol-3-Kinase Inhibition in Follicular Lymphoma" @default.
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- W3015233485 doi "https://doi.org/10.1016/j.hoc.2020.02.008" @default.
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