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- W3015242702 abstract "With the increasing necessity of animal models in biomedical research, there is a vital need to harmonise findings across species by establishing similarities and differences in rodent and primate neuroanatomy. Using connectivity fingerprint matching, we compared cortico-striatal circuits across humans, non-human primates, and mice using resting-state fMRI data in all species. Our results suggest that the connectivity patterns for the nucleus accumbens and cortico-striatal motor circuits (posterior/lateral putamen) were conserved across species, making them reliable targets for cross-species comparisons. However, a large number of human and macaque striatal voxels were not matched to any mouse cortico-striatal circuit (mouse->human: 85% unassigned; mouse->macaque 69% unassigned; macaque->human; 31% unassigned). These unassigned voxels were localised to the caudate nucleus and anterior putamen, overlapping with executive function and social/language regions of the striatum and connected to prefrontal-projecting cerebellar lobules and anterior prefrontal cortex, forming circuits that seem to be unique for non-human primates and humans." @default.
- W3015242702 created "2020-04-17" @default.
- W3015242702 creator A5035456556 @default.
- W3015242702 creator A5054708623 @default.
- W3015242702 creator A5058499321 @default.
- W3015242702 creator A5063932997 @default.
- W3015242702 creator A5074039331 @default.
- W3015242702 date "2020-04-16" @default.
- W3015242702 modified "2023-09-29" @default.
- W3015242702 title "Primate homologs of mouse cortico-striatal circuits" @default.
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