FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3015253580> ?p ?o ?g. }

• W3015253580 endingPage "2586" @default.
• W3015253580 startingPage "2586" @default.
• W3015253580 abstract "Since their invention, periodic mesoporous organosilicas (PMOs), an innovative class of materials based on organic as well as inorganic hybrid nanocomposites, have gathered enormous interest owing to their advantageous physicochemical attributes over the pristine mesoporous silica nanoparticles (MSNs). To further increase the interactions with the therapeutic guest species and subsequent compatibility as well as the physicochemical properties of PMOs, we demonstrate the post-hydroxylation of benzene-bridged PMO-based nanoparticles for photodynamic therapy (PDT). Initially, the hydrophobic benzene group in the PMO framework is modified through electrophilic substitution-assisted hydroxylation mediated by Fenton as well as Fenton-like reactions utilizing divalent and trivalent metal salts, respectively. These post-grafted PMOs with tuned hydrophobicity resulted in improved biocompatibility as well as drug loading efficiency through governing the interactions in host–guest chemistry by changing the physicochemical properties of the PMO frameworks. Furthermore, the photosensitizer, protoporphyrin IX (PpIX) molecules, encapsulated in the PMO frameworks showed a significant PDT effect in colon carcinoma (HT-29 cell line) and Gram-negative bacterial strain, Escherichia coli (E. coli). Furthermore, the light-induced cytotoxic properties in vitro are confirmed by various tests, including lactate dehydrogenase (LDH) assay for cell membrane damage and caspase assay for apoptosis determination. Indeed, the delivered PpIX molecules from PMOs generated deadly singlet oxygen species intracellularly under visible light irradiation, resulting in cell death through concomitantly triggered apoptotic caspases. Together, our findings demonstrate that this post-modified PMO design is highly advantageous and can be used as an effective PDT platform." @default.
• W3015253580 created "2020-04-17" @default.
• W3015253580 creator A5005929521 @default.
• W3015253580 creator A5015231618 @default.
• W3015253580 creator A5046085567 @default.
• W3015253580 creator A5067643630 @default.
• W3015253580 date "2020-04-08" @default.
• W3015253580 modified "2023-10-17" @default.
• W3015253580 title "Hydrophobicity-Tuned Periodic Mesoporous Organo-Silica Nanoparticles for Photodynamic Therapy" @default.
• W3015253580 cites W1544947788 @default.
• W3015253580 cites W1801425213 @default.
• W3015253580 cites W1991389652 @default.
• W3015253580 cites W2011246992 @default.
• W3015253580 cites W2013316743 @default.
• W3015253580 cites W2027286349 @default.
• W3015253580 cites W2028829354 @default.
• W3015253580 cites W2038648107 @default.
• W3015253580 cites W2040873804 @default.
• W3015253580 cites W2048056641 @default.
• W3015253580 cites W2062430513 @default.
• W3015253580 cites W2078736713 @default.
• W3015253580 cites W2092658115 @default.
• W3015253580 cites W2109809013 @default.
• W3015253580 cites W2111423624 @default.
• W3015253580 cites W2114918609 @default.
• W3015253580 cites W2118863295 @default.
• W3015253580 cites W2124660605 @default.
• W3015253580 cites W2149702053 @default.
• W3015253580 cites W2167577902 @default.
• W3015253580 cites W2284254157 @default.
• W3015253580 cites W2286257019 @default.
• W3015253580 cites W2297594477 @default.
• W3015253580 cites W2322209989 @default.
• W3015253580 cites W2344850880 @default.
• W3015253580 cites W2346680489 @default.
• W3015253580 cites W2405739694 @default.
• W3015253580 cites W2462997777 @default.
• W3015253580 cites W2469615375 @default.
• W3015253580 cites W2475393821 @default.
• W3015253580 cites W2476768641 @default.
• W3015253580 cites W2511246051 @default.
• W3015253580 cites W2530724412 @default.
• W3015253580 cites W2549411003 @default.
• W3015253580 cites W2752243232 @default.
• W3015253580 cites W2771236839 @default.
• W3015253580 cites W2780841061 @default.
• W3015253580 cites W2786121344 @default.
• W3015253580 cites W2794459171 @default.
• W3015253580 cites W2895408565 @default.
• W3015253580 cites W2911918141 @default.
• W3015253580 cites W2968794995 @default.
• W3015253580 cites W2971439062 @default.
• W3015253580 cites W2979402130 @default.
• W3015253580 cites W2993528022 @default.
• W3015253580 doi "https://doi.org/10.3390/ijms21072586" @default.
• W3015253580 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7178211" @default.
• W3015253580 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32276405" @default.
• W3015253580 hasPublicationYear "2020" @default.
• W3015253580 type Work @default.
• W3015253580 sameAs 3015253580 @default.
• W3015253580 citedByCount "10" @default.
• W3015253580 countsByYear W30152535802020 @default.
• W3015253580 countsByYear W30152535802021 @default.
• W3015253580 countsByYear W30152535802022 @default.
• W3015253580 countsByYear W30152535802023 @default.
• W3015253580 crossrefType "journal-article" @default.
• W3015253580 hasAuthorship W3015253580A5005929521 @default.
• W3015253580 hasAuthorship W3015253580A5015231618 @default.
• W3015253580 hasAuthorship W3015253580A5046085567 @default.
• W3015253580 hasAuthorship W3015253580A5067643630 @default.
• W3015253580 hasBestOaLocation W30152535801 @default.
• W3015253580 hasConcept C12554922 @default.
• W3015253580 hasConcept C155672457 @default.
• W3015253580 hasConcept C161790260 @default.
• W3015253580 hasConcept C171250308 @default.
• W3015253580 hasConcept C178790620 @default.
• W3015253580 hasConcept C185592680 @default.
• W3015253580 hasConcept C192562407 @default.
• W3015253580 hasConcept C202751555 @default.
• W3015253580 hasConcept C20639190 @default.
• W3015253580 hasConcept C21951064 @default.
• W3015253580 hasConcept C2777230088 @default.
• W3015253580 hasConcept C2777496208 @default.
• W3015253580 hasConcept C2781323092 @default.
• W3015253580 hasConcept C2781469039 @default.
• W3015253580 hasConcept C55493867 @default.
• W3015253580 hasConcept C5913796 @default.
• W3015253580 hasConcept C75473681 @default.
• W3015253580 hasConcept C82776694 @default.
• W3015253580 hasConcept C86803240 @default.
• W3015253580 hasConceptScore W3015253580C12554922 @default.
• W3015253580 hasConceptScore W3015253580C155672457 @default.
• W3015253580 hasConceptScore W3015253580C161790260 @default.
• W3015253580 hasConceptScore W3015253580C171250308 @default.
• W3015253580 hasConceptScore W3015253580C178790620 @default.
• W3015253580 hasConceptScore W3015253580C185592680 @default.
• W3015253580 hasConceptScore W3015253580C192562407 @default.
• W3015253580 hasConceptScore W3015253580C202751555 @default.

• next