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- W3015327569 abstract "The endosomal sorting complex required for transport (ESCRT) plays a crucial role in the transportation and degradation of proteins. We determined that Vps27, a key protein of the ESCRT-0 complex, is required for the transport of the virulence factor laccase to the cell wall in Cryptococcus neoformans . Laccase activity was perturbed, as was melanin production, in vps27 Δ strains. In the absence of VPS27 , there was an accumulation of multivesicular bodies with vacuolar fragmentation and mistargeting of the vacuolar carboxypeptidase CPY/Prc1, resulting in an extracellular localization." @default.
- W3015327569 created "2020-04-17" @default.
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- W3015327569 date "2020-06-22" @default.
- W3015327569 modified "2023-10-11" @default.
- W3015327569 title "Role of the ESCRT Pathway in Laccase Trafficking and Virulence of Cryptococcus neoformans" @default.
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- W3015327569 doi "https://doi.org/10.1128/iai.00954-19" @default.
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