Matches in SemOpenAlex for { <https://semopenalex.org/work/W3015387276> ?p ?o ?g. }
- W3015387276 endingPage "927" @default.
- W3015387276 startingPage "927" @default.
- W3015387276 abstract "Secondary resistant mutations in cancer cells arise in response to certain small molecule inhibitors. These mutations inevitably cause recurrence and often progression to a more aggressive form. Resistant mutations may manifest in various forms. For example, some mutations decrease or abrogate the affinity of the drug for the protein. Others restore the function of the enzyme even in the presence of the inhibitor. In some cases, resistance is acquired through activation of a parallel pathway which bypasses the function of the drug targeted pathway. The Catalogue of Somatic Mutations in Cancer (COSMIC) produced a compendium of resistant mutations to small molecule inhibitors reported in the literature. Here, we build on these data and provide a comprehensive review of resistant mutations in cancers. We also discuss mechanistic parallels of resistance." @default.
- W3015387276 created "2020-04-17" @default.
- W3015387276 creator A5076407278 @default.
- W3015387276 creator A5082614061 @default.
- W3015387276 date "2020-04-09" @default.
- W3015387276 modified "2023-09-27" @default.
- W3015387276 title "Secondary Resistant Mutations to Small Molecule Inhibitors in Cancer Cells" @default.
- W3015387276 cites W125341987 @default.
- W3015387276 cites W1491779959 @default.
- W3015387276 cites W1503281372 @default.
- W3015387276 cites W151292308 @default.
- W3015387276 cites W1515841604 @default.
- W3015387276 cites W1517472822 @default.
- W3015387276 cites W1521367633 @default.
- W3015387276 cites W1535671294 @default.
- W3015387276 cites W1546552389 @default.
- W3015387276 cites W1565211228 @default.
- W3015387276 cites W1585007400 @default.
- W3015387276 cites W1602752259 @default.
- W3015387276 cites W1732318706 @default.
- W3015387276 cites W1752312133 @default.
- W3015387276 cites W1846586690 @default.
- W3015387276 cites W1870864846 @default.
- W3015387276 cites W1881469793 @default.
- W3015387276 cites W1891334654 @default.
- W3015387276 cites W1923619280 @default.
- W3015387276 cites W1945289541 @default.
- W3015387276 cites W1963497189 @default.
- W3015387276 cites W1963731933 @default.
- W3015387276 cites W1963826141 @default.
- W3015387276 cites W1964479812 @default.
- W3015387276 cites W1964483563 @default.
- W3015387276 cites W1965295262 @default.
- W3015387276 cites W1967796318 @default.
- W3015387276 cites W1968786809 @default.
- W3015387276 cites W1968966573 @default.
- W3015387276 cites W1969790866 @default.
- W3015387276 cites W1970845550 @default.
- W3015387276 cites W1970915933 @default.
- W3015387276 cites W1971056717 @default.
- W3015387276 cites W1971154913 @default.
- W3015387276 cites W1971947883 @default.
- W3015387276 cites W1972546853 @default.
- W3015387276 cites W1973016854 @default.
- W3015387276 cites W1974903221 @default.
- W3015387276 cites W1974951679 @default.
- W3015387276 cites W1975701148 @default.
- W3015387276 cites W1976709816 @default.
- W3015387276 cites W1977728980 @default.
- W3015387276 cites W1979816280 @default.
- W3015387276 cites W1980256638 @default.
- W3015387276 cites W1980576531 @default.
- W3015387276 cites W1980834655 @default.
- W3015387276 cites W1981145667 @default.
- W3015387276 cites W1982164530 @default.
- W3015387276 cites W1984209370 @default.
- W3015387276 cites W1986051654 @default.
- W3015387276 cites W1986445986 @default.
- W3015387276 cites W1986525211 @default.
- W3015387276 cites W1988614680 @default.
- W3015387276 cites W1989121777 @default.
- W3015387276 cites W1989954597 @default.
- W3015387276 cites W1990030298 @default.
- W3015387276 cites W1990222254 @default.
- W3015387276 cites W1990516841 @default.
- W3015387276 cites W1990626198 @default.
- W3015387276 cites W1990848928 @default.
- W3015387276 cites W1991691392 @default.
- W3015387276 cites W1992945955 @default.
- W3015387276 cites W1993808852 @default.
- W3015387276 cites W1993882675 @default.
- W3015387276 cites W1994452429 @default.
- W3015387276 cites W1997457847 @default.
- W3015387276 cites W1997476230 @default.
- W3015387276 cites W1997503626 @default.
- W3015387276 cites W1998593414 @default.
- W3015387276 cites W1998622405 @default.
- W3015387276 cites W1999203646 @default.
- W3015387276 cites W1999241512 @default.
- W3015387276 cites W1999466080 @default.
- W3015387276 cites W1999614615 @default.
- W3015387276 cites W2000292756 @default.
- W3015387276 cites W2000824159 @default.
- W3015387276 cites W2001343785 @default.
- W3015387276 cites W2001430754 @default.
- W3015387276 cites W2001664183 @default.
- W3015387276 cites W2001999652 @default.
- W3015387276 cites W2002937040 @default.
- W3015387276 cites W2003402062 @default.
- W3015387276 cites W2003892998 @default.
- W3015387276 cites W2003973314 @default.
- W3015387276 cites W2003984225 @default.
- W3015387276 cites W2004822307 @default.
- W3015387276 cites W2005726906 @default.
- W3015387276 cites W2006315580 @default.
- W3015387276 cites W2006422013 @default.
- W3015387276 cites W2006786878 @default.
- W3015387276 cites W2007460969 @default.