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- W3015427816 abstract "Abstract INTRODUCTION Dementia pathogenesis begins years before clinical symptom onset, necessitating the understanding of premorbid risk mechanisms. Here, we investigated potential pathogenic mechanisms by assessing DNA methylation associations with dementia risk factors in Alzheimer’s disease (AD)-free participants. METHODS Associations between dementia risk measures (family history, genetic risk score (GRS), and dementia risk scores (combining lifestyle, demographic and genetic factors) and whole-blood DNA methylation were assessed in discovery and replication samples (n=∼400 – ∼5,000) from Generation Scotland. RESULTS AD genetic risk and two risk scores were associated with differential methylation. The GRS predominantly associated with methylation differences in cis but also identified a genomic region implicated in Parkinson’s disease. Loci associated with the risk scores were enriched for those previously associated with body mass index and alcohol consumption. DISCUSSION Dementia risk measures show widespread association with blood-based methylation, which indicates differences in the processes affected by genetic and demographic/lifestyle risk factors." @default.
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- W3015427816 date "2020-04-11" @default.
- W3015427816 modified "2023-09-27" @default.
- W3015427816 title "Epigenome-wide analyses identify DNA methylation signatures of dementia risk" @default.
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- W3015427816 doi "https://doi.org/10.1101/2020.04.06.20055517" @default.
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