Matches in SemOpenAlex for { <https://semopenalex.org/work/W3015446261> ?p ?o ?g. }
- W3015446261 endingPage "348" @default.
- W3015446261 startingPage "348" @default.
- W3015446261 abstract "The pharmacokinetics of a drug is dependent upon the coordinate work of influx transporters, enzymes and efflux transporters (i.e., transporter-enzyme interplay). The transporter–enzyme interplay may occur in liver, kidney and intestine. The influx transporters involving drug transport are organic anion transporting polypeptides (OATPs), peptide transporters (PepTs), organic anion transporters (OATs), monocarboxylate transporters (MCTs) and organic cation transporters (OCTs). The efflux transporters are P-glycoprotein (P-gp), multidrug/toxin extrusions (MATEs), multidrug resistance-associated proteins (MRPs) and breast cancer resistance protein (BCRP). The enzymes related to drug metabolism are mainly cytochrome P450 enzymes (CYP450s) and UDP-glucuronosyltransferases (UGTs). Accumulating evidence has demonstrated that diabetes alters the expression and functions of CYP450s and transporters in a different manner, disordering the transporter–enzyme interplay, in turn affecting the pharmacokinetics of some drugs. We aimed to focus on (1) the imbalance of transporter-CYP450 interplay in the liver, intestine and kidney due to altered expressions of influx transporters (OATPs, OCTs, OATs, PepTs and MCT6), efflux transporters (P-gp, BCRP and MRP2) and CYP450s (CYP3As, CYP1A2, CYP2E1 and CYP2Cs) under diabetic status; (2) the net contributions of these alterations in the expression and functions of transporters and CYP450s to drug disposition, therapeutic efficacy and drug toxicity; (3) application of a physiologically-based pharmacokinetic model in transporter–enzyme interplay." @default.
- W3015446261 created "2020-04-17" @default.
- W3015446261 creator A5035168940 @default.
- W3015446261 creator A5065171747 @default.
- W3015446261 date "2020-04-11" @default.
- W3015446261 modified "2023-09-26" @default.
- W3015446261 title "Imbalance of Drug Transporter-CYP450s Interplay by Diabetes and Its Clinical Significance" @default.
- W3015446261 cites W1493374308 @default.
- W3015446261 cites W1529777580 @default.
- W3015446261 cites W1584324651 @default.
- W3015446261 cites W1594959651 @default.
- W3015446261 cites W1824483124 @default.
- W3015446261 cites W1847367967 @default.
- W3015446261 cites W1894007534 @default.
- W3015446261 cites W1908558588 @default.
- W3015446261 cites W1950404040 @default.
- W3015446261 cites W1963544970 @default.
- W3015446261 cites W1964173044 @default.
- W3015446261 cites W1964213038 @default.
- W3015446261 cites W1965697187 @default.
- W3015446261 cites W1972996926 @default.
- W3015446261 cites W1978502180 @default.
- W3015446261 cites W1980646764 @default.
- W3015446261 cites W1982559545 @default.
- W3015446261 cites W1985141616 @default.
- W3015446261 cites W1986467319 @default.
- W3015446261 cites W1988097110 @default.
- W3015446261 cites W1988352870 @default.
- W3015446261 cites W1991652499 @default.
- W3015446261 cites W1991938984 @default.
- W3015446261 cites W1992727868 @default.
- W3015446261 cites W1993600610 @default.
- W3015446261 cites W1998226689 @default.
- W3015446261 cites W2000615749 @default.
- W3015446261 cites W2003994256 @default.
- W3015446261 cites W2004218771 @default.
- W3015446261 cites W2007149752 @default.
- W3015446261 cites W2012755572 @default.
- W3015446261 cites W2012951760 @default.
- W3015446261 cites W2014084035 @default.
- W3015446261 cites W2016753008 @default.
- W3015446261 cites W2018168242 @default.
- W3015446261 cites W2019372384 @default.
- W3015446261 cites W2022729779 @default.
- W3015446261 cites W2023522980 @default.
- W3015446261 cites W2023873540 @default.
- W3015446261 cites W2027064789 @default.
- W3015446261 cites W2027216416 @default.
- W3015446261 cites W2028096708 @default.
- W3015446261 cites W2031168111 @default.
- W3015446261 cites W2031801165 @default.
- W3015446261 cites W2034147284 @default.
- W3015446261 cites W2034354538 @default.
- W3015446261 cites W2040200462 @default.
- W3015446261 cites W2042733125 @default.
- W3015446261 cites W2042958247 @default.
- W3015446261 cites W2044119091 @default.
- W3015446261 cites W2054197433 @default.
- W3015446261 cites W2054617071 @default.
- W3015446261 cites W2055911345 @default.
- W3015446261 cites W2062097882 @default.
- W3015446261 cites W2063003329 @default.
- W3015446261 cites W2063303813 @default.
- W3015446261 cites W2064289043 @default.
- W3015446261 cites W2064952582 @default.
- W3015446261 cites W2068732634 @default.
- W3015446261 cites W2070337370 @default.
- W3015446261 cites W2077137893 @default.
- W3015446261 cites W2078726308 @default.
- W3015446261 cites W2079472273 @default.
- W3015446261 cites W2082458165 @default.
- W3015446261 cites W2084566862 @default.
- W3015446261 cites W2084791180 @default.
- W3015446261 cites W2087064037 @default.
- W3015446261 cites W2087729092 @default.
- W3015446261 cites W2089989291 @default.
- W3015446261 cites W2092115353 @default.
- W3015446261 cites W2094587010 @default.
- W3015446261 cites W2094641868 @default.
- W3015446261 cites W2095115792 @default.
- W3015446261 cites W2095896716 @default.
- W3015446261 cites W2099788931 @default.
- W3015446261 cites W2100724974 @default.
- W3015446261 cites W2101059949 @default.
- W3015446261 cites W2104689512 @default.
- W3015446261 cites W2105734177 @default.
- W3015446261 cites W2108822380 @default.
- W3015446261 cites W2118057722 @default.
- W3015446261 cites W2123460944 @default.
- W3015446261 cites W2123592347 @default.
- W3015446261 cites W2124988877 @default.
- W3015446261 cites W2126698884 @default.
- W3015446261 cites W2127620619 @default.
- W3015446261 cites W2129514669 @default.
- W3015446261 cites W2136681191 @default.
- W3015446261 cites W2137722420 @default.
- W3015446261 cites W2137936811 @default.
- W3015446261 cites W2139812338 @default.