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- W3015465193 abstract "Centrosome disjunction occurs in late G2 to facilitate bipolar spindle formation and is mediated by the NIMA-related kinase Nek2. Here, we show that GAS2L1, a microtubule- and F-actin–binding protein required for centrosome disjunction, undergoes Nek2-mediated phosphorylation at Ser352 in G2/M. The phosphorylation is essential for centrosome disjunction in late G2 and for proper spindle assembly and faithful chromosome segregation in mitosis. GAS2L1 contains a calponin-homology (CH) domain and a GAS2-related (GAR) domain, which bind to F-actin and microtubules, respectively. Notably, the CH and GAR domains bind to each other to inhibit the functions of both domains, and Ser352 phosphorylation disrupts the interaction between the two domains and relieves the autoinhibition. We dissected the roles of the GAS2L1 phosphorylation and of centrosome-linker disassembly, which is another Nek2-mediated event, and found that these events together trigger centrosome disjunction. Therefore, our findings demonstrate the concerted Nek2 actions that split the centrosomes in late G2." @default.
- W3015465193 created "2020-04-17" @default.
- W3015465193 creator A5005234975 @default.
- W3015465193 creator A5020179176 @default.
- W3015465193 creator A5062511488 @default.
- W3015465193 date "2020-04-14" @default.
- W3015465193 modified "2023-10-13" @default.
- W3015465193 title "Nek2-mediated GAS2L1 phosphorylation and centrosome-linker disassembly induce centrosome disjunction" @default.
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- W3015465193 doi "https://doi.org/10.1083/jcb.201909094" @default.
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