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• W3015501695 abstract "Background: Eletriptan is a migraine-specific drug-containing the triptan group. In terms of drug safety, the present study aimed to investigate the genotoxic potential of eletriptan.Research design & methods: We conducted our study by using the cytokinesis-block micronucleus cytome (CBMN) assay, a comprehensive method for measuring micronucleus formation, and a sensitive method for detecting DNA-strand breaks. In the assay, cytokinesis-block proliferation index and the frequency of micronuclei were evaluated in lymphocytes treated with three different concentrations (1, 10 and 25 µg/ml) of eletriptan for 48 hours. In comet assays, DNA damage was evaluated in leucocytes treated with three different concentrations (1, 10 and 25 µg/ml) of eletriptan for an hour.Results: Eletriptan did not induce cytotoxicity nor any increased micronuclei frequencies. While the comet parameters % DNA in tail, tail moment, and the olive moment was found to be significantly increased at 10 and 25 µg/ml, the cytokinesis-block proliferation index values were not.Conclusion: These findings suggest that eletriptan is non-cytotoxic but potentially weakly genotoxic at higher concentrations (10 and 25 µg/ml)." @default.
• W3015501695 created "2020-04-17" @default.
• W3015501695 creator A5006243893 @default.
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• W3015501695 date "2020-04-10" @default.
• W3015501695 modified "2023-10-18" @default.
• W3015501695 title "Assessment of the genotoxic potential of a migraine-specific drug by comet and cytokinesis-block micronucleus assays" @default.
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• W3015501695 doi "https://doi.org/10.1080/17425255.2020.1748598" @default.
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