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- W3015510204 abstract "Bull spermatozoa physiology may be modulated by melatonin. We washed ejaculated spermatozoa free of melatonin and incubated them (4 h, 38 °C) with 0-pM, 1-pM, 100-pM, 10-nM and 1-µM melatonin in TALP-HEPES (non-capacitating) and TALP-HEPES-heparin (capacitating). This range of concentrations encompassed the effects mediated by melatonin receptors (pM), intracellular targets (nM–µM) or antioxidant activity (µM). Treatment effects were assessed as motility changes by computer-assisted sperm analysis (CASA) of motility and physiological changes by flow cytometry. Melatonin effects were more evident in capacitating conditions, with 100 pM reducing motility and velocity (VCL) while increasing a “slow” subpopulation. All concentrations decreased apoptotic spermatozoa and stimulated mitochondrial activity in viable spermatozoa, with 100 pM–1 µM increasing acrosomal damage, 10 nM–1 µM increasing intracellular calcium and 1 pM reducing the response to a calcium-ionophore challenge. In non-capacitating media, 1 µM increased hyperactivation-related variables and decreased apoptotic spermatozoa; 100 pM–1 µM increased membrane disorders (related to capacitation); all concentrations decreased mitochondrial ROS production. Melatonin concentrations had a modal effect on bull spermatozoa, suggesting a capacitation-modulating role and protective effect at physiological concentrations (pM). Some effects may be of practical use, considering artificial reproductive techniques." @default.
- W3015510204 created "2020-04-17" @default.
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- W3015510204 creator A5060131253 @default.
- W3015510204 date "2020-04-13" @default.
- W3015510204 modified "2023-10-16" @default.
- W3015510204 title "Melatonin Non-Linearly Modulates Bull Spermatozoa Motility and Physiology in Capacitating and Non-Capacitating Conditions" @default.
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- W3015510204 doi "https://doi.org/10.3390/ijms21082701" @default.
- W3015510204 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7215461" @default.
- W3015510204 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32295040" @default.
- W3015510204 hasPublicationYear "2020" @default.
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