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- W3015514881 endingPage "112989" @default.
- W3015514881 startingPage "112989" @default.
- W3015514881 abstract "The finding that the drug KarXT, a formulation of xanomeline and tropsium which targets muscarinic receptors, has given a positive result in reducing the positive and negative symptoms of schizophrenia in a phase II trial suggests targeting muscarinic receptors is a new approach to treating the disorder. This review will detail the synergistic interplay between studies to understand the role of muscarinic receptors in the aetiology of schizophrenia and drug development and how this has supported the hypothesis that activating the muscarinic M1 and M4 receptors is critical to the efficacy of KarXT, in schizophrenia. The discovery of an intermediate phenotype within schizophrenia which is characterised by the presence of a marked loss of cortical muscarinic M1 receptors will be reviewed. Highlighted will be progress in understanding the biochemistry of that intermediate phenotype and evidence to suggest that those with the intermediate phenotype may resist treatment with agonist to the orthosteric site on the muscarinic M1 and M4 receptor. Finally, the possibility of using drugs targeting the allosteric binding sites on muscarinic receptors to treat schizophrenia will be discussed. This timely review will therefore highlight how research can influence hypothesis driven drug discovery that should produce new treatments for schizophrenia." @default.
- W3015514881 created "2020-04-17" @default.
- W3015514881 creator A5063663165 @default.
- W3015514881 creator A5090073956 @default.
- W3015514881 date "2020-06-01" @default.
- W3015514881 modified "2023-10-18" @default.
- W3015514881 title "Muscarinic M1 and M4 receptors: Hypothesis driven drug development for schizophrenia" @default.
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- W3015514881 cites W1551771994 @default.
- W3015514881 cites W1602753533 @default.
- W3015514881 cites W1965013287 @default.
- W3015514881 cites W1966014791 @default.
- W3015514881 cites W1976834251 @default.
- W3015514881 cites W1977415114 @default.
- W3015514881 cites W1985618379 @default.
- W3015514881 cites W2002569378 @default.
- W3015514881 cites W2013514700 @default.
- W3015514881 cites W2014260646 @default.
- W3015514881 cites W201431512 @default.
- W3015514881 cites W2019356428 @default.
- W3015514881 cites W2021128482 @default.
- W3015514881 cites W2021682666 @default.
- W3015514881 cites W2030246304 @default.
- W3015514881 cites W2035695460 @default.
- W3015514881 cites W2037661692 @default.
- W3015514881 cites W2037749055 @default.
- W3015514881 cites W2044662576 @default.
- W3015514881 cites W2045761141 @default.
- W3015514881 cites W2050512659 @default.
- W3015514881 cites W2057597102 @default.
- W3015514881 cites W2063985393 @default.
- W3015514881 cites W2066610089 @default.
- W3015514881 cites W2076657500 @default.
- W3015514881 cites W2076675457 @default.
- W3015514881 cites W2079619546 @default.
- W3015514881 cites W2081792830 @default.
- W3015514881 cites W2082642969 @default.
- W3015514881 cites W2092820864 @default.
- W3015514881 cites W2092829073 @default.
- W3015514881 cites W2098406191 @default.
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- W3015514881 cites W2112522183 @default.
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- W3015514881 cites W2156197096 @default.
- W3015514881 cites W2162881100 @default.
- W3015514881 cites W2166826909 @default.
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- W3015514881 cites W2281571957 @default.
- W3015514881 cites W2315346240 @default.
- W3015514881 cites W2328901067 @default.
- W3015514881 cites W2413128899 @default.
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- W3015514881 doi "https://doi.org/10.1016/j.psychres.2020.112989" @default.
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