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• W3015520427 endingPage "e201900520" @default.
• W3015520427 startingPage "e201900520" @default.
• W3015520427 abstract "The therapeutic expansion of Foxp3 + regulatory T cells (Tregs) shows promise for treating autoimmune and inflammatory disorders. Yet, how this treatment affects the heterogeneity and function of Tregs is not clear. Using single-cell RNA-seq analysis, we characterized 31,908 Tregs from the mice treated with a half-life extended mutant form of murine IL-2 (IL-2 mutein, IL-2M) that preferentially expanded Tregs, or mouse IgG Fc as a control. Cell clustering analysis revealed that IL-2M specifically expands multiple sub-states of Tregs with distinct expression profiles. TCR profiling with single-cell analysis uncovered Treg migration across tissues and transcriptional changes between clonally related Tregs after IL-2M treatment. Finally, we identified IL-2M–expanded Tnfrsf9 + Il1rl1 + Tregs with superior suppressive function, highlighting the potential of IL-2M to expand highly suppressive Foxp3 + Tregs." @default.
• W3015520427 created "2020-04-17" @default.
• W3015520427 creator A5005973742 @default.
• W3015520427 creator A5009047675 @default.
• W3015520427 creator A5015133038 @default.
• W3015520427 creator A5047012821 @default.
• W3015520427 creator A5047127908 @default.
• W3015520427 creator A5051365673 @default.
• W3015520427 creator A5067117690 @default.
• W3015520427 creator A5068761947 @default.
• W3015520427 date "2020-04-08" @default.
• W3015520427 modified "2023-10-13" @default.
• W3015520427 title "Dynamic changes in the regulatory T-cell heterogeneity and function by murine IL-2 mutein" @default.
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