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• W3015522882 abstract "Abstract Elevated circulating concentrations of lipoprotein(a) [Lp(a)] is strongly associated with increased risk of atherosclerotic cardiovascular disease (CVD) and degenerative aortic stenosis. This relationship was first observed in prospective observational studies, and the causal relationship was confirmed in genetic studies. Everybody should have their Lp(a) concentration measured once in their lifetime. CVD risk is elevated when Lp(a) concentrations are high i.e. > 50 mg/dL (≥100 mmol/L). Extremely high Lp(a) levels >180 mg/dL (≥430 mmol/L) are associated with CVD risk similar to that conferred by familial hypercholesterolemia. Elevated Lp(a) level was previously treated with niacin, which exerts a potent Lp(a)-lowering effect. However, niacin is currently not recommended because, despite the improvement in lipid profile, no improvements on clinical outcomes have been observed. Furthermore, niacin use has been associated with severe adverse effects. Post hoc analyses of clinical trials with proprotein convertase subtilisin/kexin type-9 (PCSK9) inhibitors have shown that these drugs exert clinical benefits by lowering Lp(a), independent of their potent reduction of low-density lipoprotein cholesterol (LDL-C). It is not yet known whether PCSK9 inhibitors will be of clinical use in patients with elevated Lp(a). Apheresis is a very effective approach to Lp(a) reduction, which reduces CVD risk but is invasive and time-consuming and is thus reserved for patients with very high Lp(a) levels and progressive CVD. Studies are ongoing on the practical application of genetic approaches to therapy, including antisense oligonucleotides against apolipoprotein(a) and small interfering RNA (siRNA) technology, to reduce the synthesis of Lp(a)." @default.
• W3015522882 created "2020-04-17" @default.
• W3015522882 creator A5036867671 @default.
• W3015522882 creator A5040885516 @default.
• W3015522882 creator A5046431472 @default.
• W3015522882 creator A5054475556 @default.
• W3015522882 date "2020-05-01" @default.
• W3015522882 modified "2023-09-24" @default.
• W3015522882 title "What do we know about the role of lipoprotein(a) in atherogenesis 57 years after its discovery?" @default.
• W3015522882 cites W1609565130 @default.
• W3015522882 cites W1856460279 @default.
• W3015522882 cites W1972444318 @default.
• W3015522882 cites W1988163135 @default.
• W3015522882 cites W1988877980 @default.
• W3015522882 cites W1990204315 @default.
• W3015522882 cites W2003239719 @default.
• W3015522882 cites W2005025769 @default.
• W3015522882 cites W2019295985 @default.
• W3015522882 cites W2020711578 @default.
• W3015522882 cites W2021847645 @default.
• W3015522882 cites W2032867296 @default.
• W3015522882 cites W2039988386 @default.
• W3015522882 cites W2086153196 @default.
• W3015522882 cites W2088314613 @default.
• W3015522882 cites W2098230963 @default.
• W3015522882 cites W2099381821 @default.
• W3015522882 cites W2101257910 @default.
• W3015522882 cites W2104355263 @default.
• W3015522882 cites W2106021276 @default.
• W3015522882 cites W2107134698 @default.
• W3015522882 cites W2111099202 @default.
• W3015522882 cites W2128025136 @default.
• W3015522882 cites W2130412576 @default.
• W3015522882 cites W2142686113 @default.
• W3015522882 cites W2146846603 @default.
• W3015522882 cites W2147696440 @default.
• W3015522882 cites W2160182135 @default.
• W3015522882 cites W2161230420 @default.
• W3015522882 cites W2165605025 @default.
• W3015522882 cites W2166005458 @default.
• W3015522882 cites W2169920876 @default.
• W3015522882 cites W2170183132 @default.
• W3015522882 cites W2180285060 @default.
• W3015522882 cites W2218954597 @default.
• W3015522882 cites W2223917560 @default.
• W3015522882 cites W2280202036 @default.
• W3015522882 cites W2285990175 @default.
• W3015522882 cites W2291663719 @default.
• W3015522882 cites W2354711610 @default.
• W3015522882 cites W2356448283 @default.
• W3015522882 cites W2418382063 @default.
• W3015522882 cites W2498232546 @default.
• W3015522882 cites W2516597936 @default.
• W3015522882 cites W2522418769 @default.
• W3015522882 cites W2526556731 @default.
• W3015522882 cites W2556080334 @default.
• W3015522882 cites W2580175644 @default.
• W3015522882 cites W2581019984 @default.
• W3015522882 cites W2587693305 @default.
• W3015522882 cites W2590380901 @default.
• W3015522882 cites W2595890376 @default.
• W3015522882 cites W2626289035 @default.
• W3015522882 cites W2782406355 @default.
• W3015522882 cites W2794221018 @default.
• W3015522882 cites W2809135070 @default.
• W3015522882 cites W2809552245 @default.
• W3015522882 cites W2892377448 @default.
• W3015522882 cites W2894645224 @default.
• W3015522882 cites W2899736836 @default.
• W3015522882 cites W2905490213 @default.
• W3015522882 cites W2909453258 @default.
• W3015522882 cites W2921601441 @default.
• W3015522882 cites W2940327706 @default.
• W3015522882 cites W2942412515 @default.
• W3015522882 cites W2943825718 @default.
• W3015522882 cites W2945006463 @default.
• W3015522882 cites W2950923840 @default.
• W3015522882 cites W2953521778 @default.
• W3015522882 cites W2966764977 @default.
• W3015522882 cites W2967802488 @default.
• W3015522882 cites W2969446803 @default.
• W3015522882 cites W2995889897 @default.
• W3015522882 cites W2996456596 @default.
• W3015522882 cites W2997944188 @default.
• W3015522882 cites W3000712048 @default.
• W3015522882 cites W3010349606 @default.
• W3015522882 cites W3011402579 @default.
• W3015522882 cites W3183857127 @default.
• W3015522882 cites W4206582562 @default.
• W3015522882 cites W4234239571 @default.
• W3015522882 cites W56038340 @default.
• W3015522882 doi "https://doi.org/10.1016/j.pcad.2020.04.004" @default.
• W3015522882 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32277995" @default.
• W3015522882 hasPublicationYear "2020" @default.
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