FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3015526782> ?p ?o ?g. }

• W3015526782 endingPage "4144" @default.
• W3015526782 startingPage "4130" @default.
• W3015526782 abstract "Information about water flow, detected by lateral line organs, is critical to the behavior and survival of fish and amphibians. While certain aspects of water flow processing have been revealed through electrophysiology, we lack a comprehensive description of the neurons that respond to water flow and the network that they form. Here, we use brain-wide calcium imaging in combination with microfluidic stimulation to map out, at cellular resolution, neuronal responses involved in perceiving and processing water flow information in larval zebrafish. We find a diverse array of neurons responding to head-to-tail (h-t) flow, tail-to-head (t-h) flow, or both. Early in this pathway, in the lateral line ganglia, neurons respond almost exclusively to the simple presence of h-t or t-h flow, but later processing includes neurons responding specifically to flow onset, representing the accumulated displacement of flow during a stimulus, or encoding the speed of the flow. The neurons reporting on these more nuanced details are located across numerous brain regions, including some not previously implicated in water flow processing. A graph theory-based analysis of the brain-wide water flow network shows that a majority of this processing is dedicated to h-t flow detection, and this is reinforced by our finding that details like flow velocity and the total accumulated flow are only encoded for the h-t direction. The results represent the first brain-wide description of processing for this important modality, and provide a departure point for more detailed studies of the flow of information through this network. SIGNIFICANCE STATEMENT In aquatic animals, the lateral line is important for detecting water flow stimuli, but the brain networks that interpret this information remain mysterious. Here, we have imaged the activity of individual neurons across the entire brains of larval zebrafish, revealing all response types and their brain locations as water flow processing occurs. We find neurons that respond to the simple presence of water flow, and others attuned to the direction, speed, and duration of flow, or the accumulated displacement of water that has passed during the stimulus. With this information, we modeled the underlying network, describing a system that is nuanced in its processing of water flow simulating head-to-tail motion but rudimentary in processing flow in the tail-to-head direction." @default.
• W3015526782 created "2020-04-17" @default.
• W3015526782 creator A5046003393 @default.
• W3015526782 creator A5049271769 @default.
• W3015526782 creator A5056420005 @default.
• W3015526782 creator A5076150919 @default.
• W3015526782 creator A5077355068 @default.
• W3015526782 date "2020-04-10" @default.
• W3015526782 modified "2023-10-02" @default.
• W3015526782 title "Brain-Wide Mapping of Water Flow Perception in Zebrafish" @default.
• W3015526782 cites W1500111801 @default.
• W3015526782 cites W1540070193 @default.
• W3015526782 cites W168089959 @default.
• W3015526782 cites W1963506121 @default.
• W3015526782 cites W1967251218 @default.
• W3015526782 cites W1969273923 @default.
• W3015526782 cites W1981716282 @default.
• W3015526782 cites W1985054631 @default.
• W3015526782 cites W2007475275 @default.
• W3015526782 cites W2015199117 @default.
• W3015526782 cites W2027361335 @default.
• W3015526782 cites W2028787575 @default.
• W3015526782 cites W2029993525 @default.
• W3015526782 cites W2036539027 @default.
• W3015526782 cites W2038406486 @default.
• W3015526782 cites W2046725266 @default.
• W3015526782 cites W2053450138 @default.
• W3015526782 cites W2054378694 @default.
• W3015526782 cites W2056614838 @default.
• W3015526782 cites W2058096862 @default.
• W3015526782 cites W2058588818 @default.
• W3015526782 cites W2065789055 @default.
• W3015526782 cites W2068364567 @default.
• W3015526782 cites W2071747803 @default.
• W3015526782 cites W2083569948 @default.
• W3015526782 cites W2087804776 @default.
• W3015526782 cites W2095872630 @default.
• W3015526782 cites W2098746383 @default.
• W3015526782 cites W2101068980 @default.
• W3015526782 cites W2106876880 @default.
• W3015526782 cites W2131938193 @default.
• W3015526782 cites W2135644005 @default.
• W3015526782 cites W2136145485 @default.
• W3015526782 cites W2136874269 @default.
• W3015526782 cites W2137701107 @default.
• W3015526782 cites W2138221697 @default.
• W3015526782 cites W2159581916 @default.
• W3015526782 cites W2167822639 @default.
• W3015526782 cites W2168486196 @default.
• W3015526782 cites W2171332611 @default.
• W3015526782 cites W2231009150 @default.
• W3015526782 cites W2277745055 @default.
• W3015526782 cites W2277956273 @default.
• W3015526782 cites W2285139664 @default.
• W3015526782 cites W2319311345 @default.
• W3015526782 cites W2612078078 @default.
• W3015526782 cites W2622155384 @default.
• W3015526782 cites W2734756181 @default.
• W3015526782 cites W2755767449 @default.
• W3015526782 cites W2792596707 @default.
• W3015526782 cites W2801497349 @default.
• W3015526782 cites W2808854098 @default.
• W3015526782 cites W2895353742 @default.
• W3015526782 cites W2897004600 @default.
• W3015526782 cites W2899993124 @default.
• W3015526782 cites W2920999799 @default.
• W3015526782 cites W2950262757 @default.
• W3015526782 cites W2950418175 @default.
• W3015526782 cites W2951770215 @default.
• W3015526782 cites W2966644074 @default.
• W3015526782 cites W2991987583 @default.
• W3015526782 cites W2996088457 @default.
• W3015526782 doi "https://doi.org/10.1523/jneurosci.0049-20.2020" @default.
• W3015526782 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7244201" @default.
• W3015526782 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32277044" @default.
• W3015526782 hasPublicationYear "2020" @default.
• W3015526782 type Work @default.
• W3015526782 sameAs 3015526782 @default.
• W3015526782 citedByCount "33" @default.
• W3015526782 countsByYear W30155267822020 @default.
• W3015526782 countsByYear W30155267822021 @default.
• W3015526782 countsByYear W30155267822022 @default.
• W3015526782 countsByYear W30155267822023 @default.
• W3015526782 crossrefType "journal-article" @default.
• W3015526782 hasAuthorship W3015526782A5046003393 @default.
• W3015526782 hasAuthorship W3015526782A5049271769 @default.
• W3015526782 hasAuthorship W3015526782A5056420005 @default.
• W3015526782 hasAuthorship W3015526782A5076150919 @default.
• W3015526782 hasAuthorship W3015526782A5077355068 @default.
• W3015526782 hasBestOaLocation W30155267821 @default.
• W3015526782 hasConcept C104317684 @default.
• W3015526782 hasConcept C121332964 @default.
• W3015526782 hasConcept C15744967 @default.
• W3015526782 hasConcept C169760540 @default.
• W3015526782 hasConcept C180747234 @default.
• W3015526782 hasConcept C185263204 @default.
• W3015526782 hasConcept C2776878037 @default.
• W3015526782 hasConcept C2779918689 @default.

• next