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- W3015536249 abstract "Organoids are becoming widespread in drug-screening technologies but have been used sparingly for cell therapy as current approaches for producing self-organized cell clusters lack scalability or reproducibility in size and cellular organization. We introduce a method of using hydrogels as sacrificial scaffolds, which allow cells to form self-organized clusters followed by gentle release, resulting in highly reproducible multicellular structures on a large scale. We demonstrated this strategy for endothelial cells and mesenchymal stem cells to self-organize into blood-vessel units, which were injected into mice, and rapidly formed perfusing vasculature. Moreover, in a mouse model of peripheral artery disease, intramuscular injections of blood-vessel units resulted in rapid restoration of vascular perfusion within seven days. As cell therapy transforms into a new class of therapeutic modality, this simple method—by making use of the dynamic nature of hydrogels—could offer high yields of self-organized multicellular aggregates with reproducible sizes and cellular architectures." @default.
- W3015536249 created "2020-04-17" @default.
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- W3015536249 date "2020-05-01" @default.
- W3015536249 modified "2023-10-16" @default.
- W3015536249 title "Injectable Therapeutic Organoids Using Sacrificial Hydrogels" @default.
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- W3015536249 doi "https://doi.org/10.1016/j.isci.2020.101052" @default.
- W3015536249 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7191221" @default.
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