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- W3015548725 endingPage "897" @default.
- W3015548725 startingPage "897" @default.
- W3015548725 abstract "The rapid activation of the type I interferon (IFN) antiviral innate immune response relies on ubiquitously expressed RNA and DNA sensors. Once engaged, these nucleotide-sensing receptors use distinct signaling modules for the rapid and robust activation of mitogen-activated protein kinases (MAPKs), the IκB kinase (IKK) complex, and the IKK-related kinases IKKε and TANK-binding kinase 1 (TBK1), leading to the subsequent activation of the activator protein 1 (AP1), nuclear factor-kappa B (NF-κB), and IFN regulatory factor 3 (IRF3) transcription factors, respectively. They, in turn, induce immunomodulatory genes, allowing for a rapid antiviral cellular response. Unlike the MAPKs, the IKK complex and the IKK-related kinases, ubiquitously expressed glycogen synthase kinase 3 (GSK-3) α and β isoforms are active in unstimulated resting cells and are involved in the constitutive turnover of β-catenin, a transcriptional coactivator involved in cell proliferation, differentiation, and lineage commitment. Interestingly, studies have demonstrated the regulatory roles of both GSK-3 and β-catenin in type I IFN antiviral innate immune response, particularly affecting the activation of IRF3. In this review, we summarize current knowledge on the mechanisms by which GSK-3 and β-catenin control the antiviral innate immune response to RNA and DNA virus infections." @default.
- W3015548725 created "2020-04-17" @default.
- W3015548725 creator A5015920069 @default.
- W3015548725 creator A5074850293 @default.
- W3015548725 creator A5081191155 @default.
- W3015548725 date "2020-04-07" @default.
- W3015548725 modified "2023-10-05" @default.
- W3015548725 title "Roles of GSK-3 and β-Catenin in Antiviral Innate Immune Sensing of Nucleic Acids" @default.
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