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- W3015559193 abstract "Multimodal properties of nanoparticles, such as simultaneously carrying drugs and/or diagnostic probes for site-specific delivery, make them excellent carriers for diagnosis and treatment of prostate cancer. Advantages are high permeability and selectivity to malignant cells to reduce systemic toxicity of chemotherapeutic drugs. Based on a review of current literature, the lack of efficient and highly specific prostate cancer cell targeting moieties is hindering successful in vivo prostate cancer-targeted drug delivery systems. Highly specific nano-targeting moieties as drug delivery vehicles might improve chemotherapeutic delivery via targeting to specific receptors expressed on the surface of prostate cancer cells. This review describes nano-targeting moieties for management of prostate cancer and its cancer stem cells. Descriptions of targeting moieties using anti-prostate-specific membrane antigen, aptamer, anti-cluster of differentiation 24/44, folic acid and other targeting strategies are highlighted. Current research results are promising and may yield development of next-generation nanoscale theragnostic targeted modalities for prostate cancer treatment." @default.
- W3015559193 created "2020-04-17" @default.
- W3015559193 creator A5020733118 @default.
- W3015559193 creator A5070873484 @default.
- W3015559193 creator A5073270821 @default.
- W3015559193 date "2020-05-01" @default.
- W3015559193 modified "2023-10-05" @default.
- W3015559193 title "Functionalized nano-targeted moieties in management of prostate cancer" @default.
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- W3015559193 doi "https://doi.org/10.2217/fon-2019-0635" @default.
- W3015559193 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32292071" @default.
- W3015559193 hasPublicationYear "2020" @default.