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• W3015603453 abstract "Purpose: Osteoporosis is more likely to cause serious complications after joint replacement, mainly due to physiological defects of endogenous osteogenic cells and the pathological osteoclast activity. It is a feasible solution to design a prosthetic surface that specifically addresses this troublesome situation. Methods: A novel three-dimensional (3D) inorganic-organic supramolecular bioactive interface was constructed consisting of stiff 3D printing porous metal scaffold and soft multifunctional, self-healable, injectable, and biodegradable supramolecular polysaccharide hydrogel. Apart from mimicking the bone extracellular matrix, the bioactive could also encapsulate bioactive substances, namely bone marrow mesenchymal stem cells (BMSCs) and bone morphogenetic protein-2 (BMP-2). A series of in vitro characterizations, such as topography and mechanical characterization, in vitro release of BMP-2, biocompatibility analysis, and osteogenic induction of BMSCs were carried out. After that, the in vivo osseointegration effect of the bioactive was investigated in detail using an osteoporotic model. Results: The administration of injectable supramolecular hydrogel into the inner pores of 3D printing porous metal scaffold could obviously change the morphology of BMSCs and facilitate its cell proliferation. Meanwhile, BMP-2 was capable of being sustained released from supramolecular hydrogel, and subsequently induced osteogenic differentiation of BMSCs and promoted the integration of the metal microspores-bone in vitro and in vivo. Moreover, the osteoporosis condition of bone around the bioactive was significantly ameliorated. Conclusion: This study demonstrates that the 3D inorganic-organic supramolecular bioactive can serve as a novel artificial prosthesis for various osteogenesis-deficient patients, such as osteoporosis and rheumatoid arthritis." @default.
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• W3015603453 date "2020-01-01" @default.
• W3015603453 modified "2023-10-17" @default.
• W3015603453 title "Enhanced osseointegration of three-dimensional supramolecular bioactive interface through osteoporotic microenvironment regulation" @default.
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• W3015603453 doi "https://doi.org/10.7150/thno.43736" @default.
• W3015603453 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7163459" @default.
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