Matches in SemOpenAlex for { <https://semopenalex.org/work/W3015646971> ?p ?o ?g. }
Showing items 1 to 83 of
83
with 100 items per page.
- W3015646971 abstract "Background The emergence and spread of multidrug resistance to antibiotics used to treat gonorrhoea has resulted in a dramatic loss of effective regimens for the condition. Currently, the extended spectrum cephalosporin, ceftriaxone, is the only viable monotherapy option available, however, resistance to this last line treatment is now emerging globally. Herein, we assessed the in vitro activity of a novel small molecule antimicrobial with a new mechanism of action, SMT-571, against a large collection of N. gonorrhoeae clinical isolates and reference strains including numerous MDR and XDR gonococcal isolates. Methods MICs (mg/L) of SMT-571 were determined by agar dilution according to current CLSI guidelines. The MICs of ceftriaxone, cefixime, azithromycin, ciprofloxacin, spectinomycin, tetracycline, and ampicillin were determined using the Etest method (AB bioMerieux, Marcy l’Etoile, France). Results SMT-571 showed potent in vitro activity against all the tested N. gonorrhoeae isolates (n=262) with MICs ranging from 0.064 to 0.125 mg/L, and the MIC50, MIC90 and modal MIC were all 0.125 mg/L. The compound was not influenced by pre-existing resistance mechanisms with no cross-resistance or correlation between the MICs of SMT-571 and comparator agents being observed. Conclusion This study is the first broad evaluation of the in vitro activities of a new mechanism, novel small molecule antimicrobial for the treatment of gonorrhoea. SMT-571 demonstrated high in vitro activity against a large geographically, temporally and genetically diverse collection of clinical N. gonorrhoeae isolates and international reference strains, including various types of high-level resistant, MDR and XDR gonococcal isolates. Disclosure No significant relationships." @default.
- W3015646971 created "2020-04-17" @default.
- W3015646971 creator A5056363494 @default.
- W3015646971 creator A5069331686 @default.
- W3015646971 creator A5069892567 @default.
- W3015646971 creator A5080439362 @default.
- W3015646971 creator A5087870029 @default.
- W3015646971 date "2019-07-01" @default.
- W3015646971 modified "2023-09-23" @default.
- W3015646971 title "P673 In-vitroactivity of SMT-571 and comparators against clinical isolates and reference strains ofneisseria gonorrhoeae" @default.
- W3015646971 doi "https://doi.org/10.1136/sextrans-2019-sti.740" @default.
- W3015646971 hasPublicationYear "2019" @default.
- W3015646971 type Work @default.
- W3015646971 sameAs 3015646971 @default.
- W3015646971 citedByCount "0" @default.
- W3015646971 crossrefType "proceedings-article" @default.
- W3015646971 hasAuthorship W3015646971A5056363494 @default.
- W3015646971 hasAuthorship W3015646971A5069331686 @default.
- W3015646971 hasAuthorship W3015646971A5069892567 @default.
- W3015646971 hasAuthorship W3015646971A5080439362 @default.
- W3015646971 hasAuthorship W3015646971A5087870029 @default.
- W3015646971 hasBestOaLocation W30156469711 @default.
- W3015646971 hasConcept C133936738 @default.
- W3015646971 hasConcept C176947019 @default.
- W3015646971 hasConcept C2776021129 @default.
- W3015646971 hasConcept C2776520383 @default.
- W3015646971 hasConcept C2778063948 @default.
- W3015646971 hasConcept C2778243283 @default.
- W3015646971 hasConcept C2778512257 @default.
- W3015646971 hasConcept C2779166590 @default.
- W3015646971 hasConcept C2780493024 @default.
- W3015646971 hasConcept C2780923616 @default.
- W3015646971 hasConcept C4937899 @default.
- W3015646971 hasConcept C501593827 @default.
- W3015646971 hasConcept C64778159 @default.
- W3015646971 hasConcept C71924100 @default.
- W3015646971 hasConcept C86803240 @default.
- W3015646971 hasConcept C89423630 @default.
- W3015646971 hasConcept C94665300 @default.
- W3015646971 hasConceptScore W3015646971C133936738 @default.
- W3015646971 hasConceptScore W3015646971C176947019 @default.
- W3015646971 hasConceptScore W3015646971C2776021129 @default.
- W3015646971 hasConceptScore W3015646971C2776520383 @default.
- W3015646971 hasConceptScore W3015646971C2778063948 @default.
- W3015646971 hasConceptScore W3015646971C2778243283 @default.
- W3015646971 hasConceptScore W3015646971C2778512257 @default.
- W3015646971 hasConceptScore W3015646971C2779166590 @default.
- W3015646971 hasConceptScore W3015646971C2780493024 @default.
- W3015646971 hasConceptScore W3015646971C2780923616 @default.
- W3015646971 hasConceptScore W3015646971C4937899 @default.
- W3015646971 hasConceptScore W3015646971C501593827 @default.
- W3015646971 hasConceptScore W3015646971C64778159 @default.
- W3015646971 hasConceptScore W3015646971C71924100 @default.
- W3015646971 hasConceptScore W3015646971C86803240 @default.
- W3015646971 hasConceptScore W3015646971C89423630 @default.
- W3015646971 hasConceptScore W3015646971C94665300 @default.
- W3015646971 hasLocation W30156469711 @default.
- W3015646971 hasOpenAccess W3015646971 @default.
- W3015646971 hasPrimaryLocation W30156469711 @default.
- W3015646971 hasRelatedWork W1573895124 @default.
- W3015646971 hasRelatedWork W1972178535 @default.
- W3015646971 hasRelatedWork W1988443793 @default.
- W3015646971 hasRelatedWork W2120102286 @default.
- W3015646971 hasRelatedWork W2131030852 @default.
- W3015646971 hasRelatedWork W2141123794 @default.
- W3015646971 hasRelatedWork W2318074519 @default.
- W3015646971 hasRelatedWork W2351114496 @default.
- W3015646971 hasRelatedWork W2356325076 @default.
- W3015646971 hasRelatedWork W2357249448 @default.
- W3015646971 hasRelatedWork W2375362425 @default.
- W3015646971 hasRelatedWork W2538106199 @default.
- W3015646971 hasRelatedWork W2622409157 @default.
- W3015646971 hasRelatedWork W2784110765 @default.
- W3015646971 hasRelatedWork W2948530572 @default.
- W3015646971 hasRelatedWork W2968860971 @default.
- W3015646971 hasRelatedWork W3111864677 @default.
- W3015646971 hasRelatedWork W3157761766 @default.
- W3015646971 hasRelatedWork W3205232230 @default.
- W3015646971 hasRelatedWork W3207154041 @default.
- W3015646971 isParatext "false" @default.
- W3015646971 isRetracted "false" @default.
- W3015646971 magId "3015646971" @default.
- W3015646971 workType "article" @default.