Matches in SemOpenAlex for { <https://semopenalex.org/work/W3015657079> ?p ?o ?g. }
- W3015657079 endingPage "75" @default.
- W3015657079 startingPage "58" @default.
- W3015657079 abstract "Summary Women who conceive at 35 years of age or older, commonly known as advanced maternal age, have a higher risk of facing parturition complications and their children have an increased risk of developing diseases later in life. However, the immunological mechanisms underlying these pathological processes have yet to be established. To fill this gap in knowledge, using a murine model and immunophenotyping, we determined the effect of advanced maternal age on the main cellular branch of adaptive immunity, T cells, at the maternal–fetal interface and in the offspring. We report that advanced maternal age impaired the process of labor at term, inducing dystocia and delaying the timing of delivery. Advanced maternal age diminished the number of specific proinflammatory T-cell subsets [T helper type 1 (Th1): CD4+IFN-γ+, CD8+IFN-γ+ and Th9: CD4+IL-9+], as well as CD4+ regulatory T cells (CD4+CD25+FoxP3+ T cells), at the maternal–fetal interface prior to term labor. Advanced maternal age also altered fetal growth and survival of the offspring in early life. In addition, infants born to advanced-age mothers had alterations in the T-cell repertoire but not in CD71+ erythroid cells (CD3−CD71+TER119+ cells). This study provides insight into the immune alterations observed at the maternal–fetal interface of advanced-age mothers and their offspring." @default.
- W3015657079 created "2020-04-17" @default.
- W3015657079 creator A5012191640 @default.
- W3015657079 creator A5025069515 @default.
- W3015657079 creator A5031657438 @default.
- W3015657079 creator A5049564110 @default.
- W3015657079 creator A5059225656 @default.
- W3015657079 creator A5067511554 @default.
- W3015657079 creator A5078309502 @default.
- W3015657079 creator A5084546771 @default.
- W3015657079 date "2020-05-07" @default.
- W3015657079 modified "2023-10-18" @default.
- W3015657079 title "The effects of advanced maternal age on T-cell subsets at the maternal–fetal interface prior to term labor and in the offspring: a mouse study" @default.
- W3015657079 cites W105894960 @default.
- W3015657079 cites W1245636590 @default.
- W3015657079 cites W1528802873 @default.
- W3015657079 cites W1532660854 @default.
- W3015657079 cites W1546063326 @default.
- W3015657079 cites W1563950821 @default.
- W3015657079 cites W1600610840 @default.
- W3015657079 cites W1625374847 @default.
- W3015657079 cites W1656197775 @default.
- W3015657079 cites W1684740056 @default.
- W3015657079 cites W1723019063 @default.
- W3015657079 cites W1829274041 @default.
- W3015657079 cites W1942668068 @default.
- W3015657079 cites W195243148 @default.
- W3015657079 cites W1963915233 @default.
- W3015657079 cites W1963924490 @default.
- W3015657079 cites W1968843604 @default.
- W3015657079 cites W1968918322 @default.
- W3015657079 cites W1971736657 @default.
- W3015657079 cites W1973429877 @default.
- W3015657079 cites W1973905104 @default.
- W3015657079 cites W1975724808 @default.
- W3015657079 cites W1979514172 @default.
- W3015657079 cites W1980697738 @default.
- W3015657079 cites W1981228751 @default.
- W3015657079 cites W1982603272 @default.
- W3015657079 cites W1983268079 @default.
- W3015657079 cites W1984815927 @default.
- W3015657079 cites W1985908235 @default.
- W3015657079 cites W1987628377 @default.
- W3015657079 cites W1989666280 @default.
- W3015657079 cites W1990845589 @default.
- W3015657079 cites W1991471550 @default.
- W3015657079 cites W1993271798 @default.
- W3015657079 cites W1993714926 @default.
- W3015657079 cites W1994864933 @default.
- W3015657079 cites W1995188134 @default.
- W3015657079 cites W1995581024 @default.
- W3015657079 cites W2000593460 @default.
- W3015657079 cites W2001015851 @default.
- W3015657079 cites W2002090731 @default.
- W3015657079 cites W2002314341 @default.
- W3015657079 cites W2002726823 @default.
- W3015657079 cites W2004708987 @default.
- W3015657079 cites W2009423286 @default.
- W3015657079 cites W2010074376 @default.
- W3015657079 cites W2016617417 @default.
- W3015657079 cites W2018020394 @default.
- W3015657079 cites W2018141882 @default.
- W3015657079 cites W2020049891 @default.
- W3015657079 cites W2021603971 @default.
- W3015657079 cites W2022196368 @default.
- W3015657079 cites W2023810230 @default.
- W3015657079 cites W2024257797 @default.
- W3015657079 cites W2027809616 @default.
- W3015657079 cites W2032304205 @default.
- W3015657079 cites W2036270966 @default.
- W3015657079 cites W2036479825 @default.
- W3015657079 cites W2038019990 @default.
- W3015657079 cites W2039416528 @default.
- W3015657079 cites W2041664430 @default.
- W3015657079 cites W2045011377 @default.
- W3015657079 cites W2045833234 @default.
- W3015657079 cites W2050741430 @default.
- W3015657079 cites W2052873213 @default.
- W3015657079 cites W2053047518 @default.
- W3015657079 cites W2053430087 @default.
- W3015657079 cites W2054232471 @default.
- W3015657079 cites W2055706903 @default.
- W3015657079 cites W2056568549 @default.
- W3015657079 cites W2057206415 @default.
- W3015657079 cites W2059122942 @default.
- W3015657079 cites W2059788501 @default.
- W3015657079 cites W2062142808 @default.
- W3015657079 cites W2062501175 @default.
- W3015657079 cites W2063754404 @default.
- W3015657079 cites W2065982486 @default.
- W3015657079 cites W2066740231 @default.
- W3015657079 cites W2072509185 @default.
- W3015657079 cites W2074909540 @default.
- W3015657079 cites W2076798898 @default.
- W3015657079 cites W2079078167 @default.
- W3015657079 cites W2082051584 @default.
- W3015657079 cites W2082839336 @default.
- W3015657079 cites W2084568545 @default.