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- W3015686080 abstract "Abstract The oocyte cytoplasm can reprogram the somatic cell nucleus into a totipotent state, but with low efficiency. The spatiotemporal chromatin organization of somatic cell nuclear transfer (SCNT) embryos remains elusive. Here, we examine higher order chromatin structures of mouse SCNT embryos using a low-input Hi-C method. We find that donor cell chromatin transforms to the metaphase state rapidly after SCNT along with the dissolution of typical 3D chromatin structure. Intriguingly, the genome undergoes a mitotic metaphase-like to meiosis metaphase II-like transition following activation. Subsequently, weak chromatin compartments and topologically associating domains (TADs) emerge following metaphase exit. TADs are further removed until the 2-cell stage before being progressively reestablished. Obvious defects including stronger TAD boundaries, aberrant super-enhancer and promoter interactions are found in SCNT embryos. These defects are partially caused by inherited H3K9me3, and can be rescued by Kdm4d overexpression. These observations provide insight into chromatin architecture reorganization during SCNT embryo development." @default.
- W3015686080 created "2020-04-17" @default.
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- W3015686080 date "2020-04-14" @default.
- W3015686080 modified "2023-10-15" @default.
- W3015686080 title "Chromatin architecture reorganization in murine somatic cell nuclear transfer embryos" @default.
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- W3015686080 doi "https://doi.org/10.1038/s41467-020-15607-z" @default.
- W3015686080 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7156422" @default.
- W3015686080 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32286279" @default.
- W3015686080 hasPublicationYear "2020" @default.
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