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- W301568715 abstract "This chapter explores the role of prostacyclin in human bronchial smooth muscle tone. In a study described in the chapter, bronchial smooth muscles of surgically removed human lungs were studied. The surgical specimens were obtained within 45 min after operation from macroscopically normal parts of the human lung, which had been removed during surgery for carcinoma. The lung specimens were taken to the laboratory in oxygenated Krebs solution. Suitable second-order bronchi with an outer diameter of 6–8 mm or third order bronchi with diameter of 3–6 mm were dissected and placed in oxygenated Krebs solution at a temperature of 23°C. Helically cut strips were prepared and suspended in an organ bath containing Krebs solution gassed with a mixture of 95% O2 + 5% CO2 and maintained at 37°C. The initial tension after 20 min equilibration was adjusted to 0.5 g for bronchial strips. 14 out of 18 preparations responded to stimulation and to histamine administration. The results showed that responses of the bronchial strips to stimulation depended on frequency, length of train, and pulse duration applied. A train of 20 pulses at low frequencies, especially with short pulse duration, produced only contraction." @default.
- W301568715 created "2016-06-24" @default.
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- W301568715 date "1981-01-01" @default.
- W301568715 modified "2023-10-16" @default.
- W301568715 title "ROLE OF PROSTACYCLIN IN HUMAN BRONCHIAL SMOOTH MUSCLE TONE" @default.
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- W301568715 doi "https://doi.org/10.1016/b978-0-08-026823-1.50044-2" @default.
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