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• W3015772757 endingPage "1779" @default.
• W3015772757 startingPage "1779" @default.
• W3015772757 abstract "A G-rich sequence containing three loops to connect four G-tracts with each ≥2 guanines can possibly form G-quadruplex structures. Given that all G-quadruplex structures comprise the stacking of G-quartets, the loop sequence plays a major role on their folding topology and thermal stability. Here circular dichroism, NMR, and PAGE are used to study the effect of loop length and base composition in the middle loop, and a single base difference in loop 1 and 3 on G-quadruplex formation of (G3HG3NmG3HG3) sequences with and without flanking nucleotides, where H is T, A, or C and N is T, A, C, or G. In addition, melting curve for G-quadruplex unfolding was used to provide relatively thermal stability of G-quadruplex structure after the addition of K+ overnight. We further studied the effects of K+ concentration on their stability and found structural changes in several sequences. Such (G3HG3NmG3HG3) configuration can be found in a number of native DNA sequences. The study of structural diversity and similarity from these sequences may allow us to establish the correlation between model sequences and native sequences. Moreover, several sequences upon interaction with a G-quadruplex ligand, BMVC, show similar spectral change, implying that structural similarity is crucial for drug development." @default.
• W3015772757 created "2020-04-17" @default.
• W3015772757 creator A5034403197 @default.
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• W3015772757 date "2020-04-13" @default.
• W3015772757 modified "2023-09-23" @default.
• W3015772757 title "Effects of Length and Loop Composition on Structural Diversity and Similarity of (G3TG3NmG3TG3) G-Quadruplexes" @default.
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• W3015772757 doi "https://doi.org/10.3390/molecules25081779" @default.
• W3015772757 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7221631" @default.
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• W3015772757 hasPublicationYear "2020" @default.
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