FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3015779924> ?p ?o ?g. }

• W3015779924 endingPage "517" @default.
• W3015779924 startingPage "509" @default.
• W3015779924 abstract "Objectives To determine the physiologic and behavioral effects and pharmacokinetic profile of hydromorphone administered intravenously (IV) to horses. Study design Prospective, randomized, crossover study. Animals A group of six adult healthy horses weighing 585.2 ± 58.7 kg. Methods Each horse was administered IV hydromorphone (0.025 mg kg–1; treatment H0.025), hydromorphone (0.05 mg kg–1; treatment H0.05) or 0.9% saline in random order with a 7 day washout period. For each treatment, physiologic, hematologic, abdominal borborygmi scores and behavioral data were recorded over 5 hours and fecal output was totaled over 24 hours. Data were analyzed using repeated measures anova with significance at p < 0.05. Blood samples were collected in treatment H0.05 for quantification of plasma hydromorphone and hydromorphone-3-glucuronide and subsequent pharmacokinetic parameter calculation. Results Hydromorphone administration resulted in a dose-dependent increase in heart rate (HR) and systolic arterial pressure (SAP). HR and SAP were 59 ± 17 beats minute–1 and 230 ± 27 mmHg, respectively, in treatment H0.05 at 5 minutes after administration. No clinically relevant changes in respiratory rate, arterial gases or temperature were observed. The borborygmi scores in both hydromorphone treatments were lower than baseline values for 2 hours. Fecal output did not differ among treatments and no evidence of abdominal discomfort was observed. Recorded behaviors did not differ among treatments. For hydromorphone, mean ± standard deviation for volume of distribution at steady state, total systemic clearance and area under the curve until the last measured concentration were 1.00 ± 0.29 L kg–1, 106 ± 21 mL minute–1 kg–1 and 8.0 ± 1.5 ng hour mL–1, respectively. Conclusions and clinical relevance Hydromorphone administered IV to healthy horses increased HR and SAP, decreased abdominal borborygmi and did not affect fecal output." @default.
• W3015779924 created "2020-04-17" @default.
• W3015779924 creator A5014749967 @default.
• W3015779924 creator A5016055349 @default.
• W3015779924 creator A5020124134 @default.
• W3015779924 creator A5067327770 @default.
• W3015779924 creator A5075325892 @default.
• W3015779924 creator A5083889662 @default.
• W3015779924 date "2020-07-01" @default.
• W3015779924 modified "2023-10-13" @default.
• W3015779924 title "Pharmacokinetics and pharmacodynamics of hydromorphone hydrochloride in healthy horses" @default.
• W3015779924 cites W1957280721 @default.
• W3015779924 cites W1967270332 @default.
• W3015779924 cites W1973443455 @default.
• W3015779924 cites W1974088718 @default.
• W3015779924 cites W1977620460 @default.
• W3015779924 cites W199624722 @default.
• W3015779924 cites W2018656722 @default.
• W3015779924 cites W2025513099 @default.
• W3015779924 cites W2026900409 @default.
• W3015779924 cites W2082140245 @default.
• W3015779924 cites W2084219274 @default.
• W3015779924 cites W2084631516 @default.
• W3015779924 cites W2088777846 @default.
• W3015779924 cites W2093095074 @default.
• W3015779924 cites W2105062536 @default.
• W3015779924 cites W2132140312 @default.
• W3015779924 cites W2149705128 @default.
• W3015779924 cites W2150323419 @default.
• W3015779924 cites W2155077634 @default.
• W3015779924 cites W2429609238 @default.
• W3015779924 cites W2490222194 @default.
• W3015779924 cites W2578882423 @default.
• W3015779924 cites W2901707085 @default.
• W3015779924 cites W2951685590 @default.
• W3015779924 doi "https://doi.org/10.1016/j.vaa.2020.03.005" @default.
• W3015779924 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32409257" @default.
• W3015779924 hasPublicationYear "2020" @default.
• W3015779924 type Work @default.
• W3015779924 sameAs 3015779924 @default.
• W3015779924 citedByCount "3" @default.
• W3015779924 countsByYear W30157799242022 @default.
• W3015779924 countsByYear W30157799242023 @default.
• W3015779924 crossrefType "journal-article" @default.
• W3015779924 hasAuthorship W3015779924A5014749967 @default.
• W3015779924 hasAuthorship W3015779924A5016055349 @default.
• W3015779924 hasAuthorship W3015779924A5020124134 @default.
• W3015779924 hasAuthorship W3015779924A5067327770 @default.
• W3015779924 hasAuthorship W3015779924A5075325892 @default.
• W3015779924 hasAuthorship W3015779924A5083889662 @default.
• W3015779924 hasBestOaLocation W30157799241 @default.
• W3015779924 hasConcept C111113717 @default.
• W3015779924 hasConcept C112705442 @default.
• W3015779924 hasConcept C126322002 @default.
• W3015779924 hasConcept C139254425 @default.
• W3015779924 hasConcept C142724271 @default.
• W3015779924 hasConcept C170493617 @default.
• W3015779924 hasConcept C204787440 @default.
• W3015779924 hasConcept C27081682 @default.
• W3015779924 hasConcept C2777397205 @default.
• W3015779924 hasConcept C2777953023 @default.
• W3015779924 hasConcept C2779158186 @default.
• W3015779924 hasConcept C2781063702 @default.
• W3015779924 hasConcept C42219234 @default.
• W3015779924 hasConcept C71924100 @default.
• W3015779924 hasConcept C84393581 @default.
• W3015779924 hasConcept C87813604 @default.
• W3015779924 hasConcept C98274493 @default.
• W3015779924 hasConceptScore W3015779924C111113717 @default.
• W3015779924 hasConceptScore W3015779924C112705442 @default.
• W3015779924 hasConceptScore W3015779924C126322002 @default.
• W3015779924 hasConceptScore W3015779924C139254425 @default.
• W3015779924 hasConceptScore W3015779924C142724271 @default.
• W3015779924 hasConceptScore W3015779924C170493617 @default.
• W3015779924 hasConceptScore W3015779924C204787440 @default.
• W3015779924 hasConceptScore W3015779924C27081682 @default.
• W3015779924 hasConceptScore W3015779924C2777397205 @default.
• W3015779924 hasConceptScore W3015779924C2777953023 @default.
• W3015779924 hasConceptScore W3015779924C2779158186 @default.
• W3015779924 hasConceptScore W3015779924C2781063702 @default.
• W3015779924 hasConceptScore W3015779924C42219234 @default.
• W3015779924 hasConceptScore W3015779924C71924100 @default.
• W3015779924 hasConceptScore W3015779924C84393581 @default.
• W3015779924 hasConceptScore W3015779924C87813604 @default.
• W3015779924 hasConceptScore W3015779924C98274493 @default.
• W3015779924 hasFunder F4320332299 @default.
• W3015779924 hasIssue "4" @default.
• W3015779924 hasLocation W30157799241 @default.
• W3015779924 hasOpenAccess W3015779924 @default.
• W3015779924 hasPrimaryLocation W30157799241 @default.
• W3015779924 hasRelatedWork W144150090 @default.
• W3015779924 hasRelatedWork W2011223819 @default.
• W3015779924 hasRelatedWork W2029317765 @default.
• W3015779924 hasRelatedWork W2122273712 @default.
• W3015779924 hasRelatedWork W2131877065 @default.
• W3015779924 hasRelatedWork W2156393504 @default.
• W3015779924 hasRelatedWork W2319099290 @default.
• W3015779924 hasRelatedWork W2440060870 @default.

• next