FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3015784712> ?p ?o ?g. }

• W3015784712 endingPage "112" @default.
• W3015784712 startingPage "105" @default.
• W3015784712 abstract "The Charcot-Leyden crystal protein (CLC-P), a constituent of human and not mouse eosinophils, is one of the most abundant proteins within human eosinophils. It has a propensity to form crystalline structures, Charcot-Leyden crystals, which are hallmarks in their distinctive extracellular crystalline forms as markers of eosinophilic inflammation. The functions of CLC-P within eosinophils have been uncertain. Although the action of CLC-P as a lysophospholipase has been questioned, assays of chromatographically purified CLC-P and crystal-derived CLC-P as well as studies of transfected recombinant CLC-P have consistently documented that CLC-P endogenously expresses lysophospholipase activity, releasing free palmitate from substrate lysopalmitoylphosphatidylcholine. Rather than acting solely as a hydrolytic enzyme to release palmitate from a lysolipid substrate, some other lysophospholipases function more dominantly as acyl-protein thioesterases (APTs), enzymes that catalyze the removal of thioester-linked, long chain fatty acids, such as palmitate, from cysteine residues of proteins. As such APTs participate in palmitoylation, a post-translational modification that can affect membrane localization, vesicular transport, and secretion. CLC-P has attributes of an APT. Thus, whereas CLC-P expresses inherent lysophospholipase activity, like some other lysophospholipase enzymes, it likely also functions in regulating the dynamic palmitoylation cycle, including, given its dominant subplasmalemmal location, at the human eosinophil's plasma membrane." @default.
• W3015784712 created "2020-04-17" @default.
• W3015784712 creator A5022885245 @default.
• W3015784712 creator A5052269140 @default.
• W3015784712 creator A5057608101 @default.
• W3015784712 date "2020-04-09" @default.
• W3015784712 modified "2023-10-18" @default.
• W3015784712 title "The Charcot–Leyden crystal protein revisited—A lysopalmitoylphospholipase and more" @default.
• W3015784712 cites W129273190 @default.
• W3015784712 cites W1429125688 @default.
• W3015784712 cites W1497664421 @default.
• W3015784712 cites W1502795635 @default.
• W3015784712 cites W1576289006 @default.
• W3015784712 cites W1608501391 @default.
• W3015784712 cites W168015647 @default.
• W3015784712 cites W1975421091 @default.
• W3015784712 cites W1978407884 @default.
• W3015784712 cites W1986504930 @default.
• W3015784712 cites W1987259015 @default.
• W3015784712 cites W1988030748 @default.
• W3015784712 cites W1997754673 @default.
• W3015784712 cites W2016952830 @default.
• W3015784712 cites W2018600215 @default.
• W3015784712 cites W2033883930 @default.
• W3015784712 cites W2037566451 @default.
• W3015784712 cites W2040196225 @default.
• W3015784712 cites W2068612489 @default.
• W3015784712 cites W2072169951 @default.
• W3015784712 cites W2081481124 @default.
• W3015784712 cites W2088962520 @default.
• W3015784712 cites W2091263537 @default.
• W3015784712 cites W20948780 @default.
• W3015784712 cites W2096246094 @default.
• W3015784712 cites W2096477148 @default.
• W3015784712 cites W2116602373 @default.
• W3015784712 cites W2120362335 @default.
• W3015784712 cites W2123229883 @default.
• W3015784712 cites W2134707857 @default.
• W3015784712 cites W2143891831 @default.
• W3015784712 cites W2155494562 @default.
• W3015784712 cites W2158292455 @default.
• W3015784712 cites W2162884305 @default.
• W3015784712 cites W2164141963 @default.
• W3015784712 cites W2171840644 @default.
• W3015784712 cites W2202608225 @default.
• W3015784712 cites W2212759803 @default.
• W3015784712 cites W2230696982 @default.
• W3015784712 cites W2244606885 @default.
• W3015784712 cites W2288301981 @default.
• W3015784712 cites W2310102111 @default.
• W3015784712 cites W2401035952 @default.
• W3015784712 cites W2412178763 @default.
• W3015784712 cites W2415836162 @default.
• W3015784712 cites W2581745547 @default.
• W3015784712 cites W2743373684 @default.
• W3015784712 cites W2747021963 @default.
• W3015784712 cites W2781319759 @default.
• W3015784712 cites W2782354676 @default.
• W3015784712 cites W2800162326 @default.
• W3015784712 cites W2888967065 @default.
• W3015784712 cites W2899881486 @default.
• W3015784712 cites W2900476334 @default.
• W3015784712 cites W2904489423 @default.
• W3015784712 cites W2919002166 @default.
• W3015784712 cites W2946429186 @default.
• W3015784712 cites W2948752241 @default.
• W3015784712 cites W2950290730 @default.
• W3015784712 cites W2971937499 @default.
• W3015784712 cites W3008814576 @default.
• W3015784712 cites W4211023012 @default.
• W3015784712 cites W4233242988 @default.
• W3015784712 cites W4237453513 @default.
• W3015784712 doi "https://doi.org/10.1002/jlb.3mr0320-319rr" @default.
• W3015784712 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32272499" @default.
• W3015784712 hasPublicationYear "2020" @default.
• W3015784712 type Work @default.
• W3015784712 sameAs 3015784712 @default.
• W3015784712 citedByCount "11" @default.
• W3015784712 countsByYear W30157847122020 @default.
• W3015784712 countsByYear W30157847122021 @default.
• W3015784712 countsByYear W30157847122022 @default.
• W3015784712 countsByYear W30157847122023 @default.
• W3015784712 crossrefType "journal-article" @default.
• W3015784712 hasAuthorship W3015784712A5022885245 @default.
• W3015784712 hasAuthorship W3015784712A5052269140 @default.
• W3015784712 hasAuthorship W3015784712A5057608101 @default.
• W3015784712 hasBestOaLocation W30157847122 @default.
• W3015784712 hasConcept C104317684 @default.
• W3015784712 hasConcept C12927208 @default.
• W3015784712 hasConcept C146727910 @default.
• W3015784712 hasConcept C181199279 @default.
• W3015784712 hasConcept C190283241 @default.
• W3015784712 hasConcept C193469717 @default.
• W3015784712 hasConcept C203522944 @default.
• W3015784712 hasConcept C2778530336 @default.
• W3015784712 hasConcept C2778834346 @default.
• W3015784712 hasConcept C2779201268 @default.
• W3015784712 hasConcept C28406088 @default.

• next