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- W3015797184 abstract "Dysregulation of cellular pH is frequent in solid tumours and provides potential opportunities for therapeutic intervention. The acidic microenvironment within a tumour can promote migration, invasion and metastasis of cancer cells through a variety of mechanisms. Pathways associated with the control of intracellular pH that are under consideration for intervention include carbonic anhydrase IX, the monocarboxylate transporters (MCT, MCT1 and MCT4), the vacuolar-type H+-ATPase proton pump, and the sodium-hydrogen exchanger 1. This review will describe progress in the development of inhibitors to these targets." @default.
- W3015797184 created "2020-04-17" @default.
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- W3015797184 creator A5090309085 @default.
- W3015797184 date "2020-04-09" @default.
- W3015797184 modified "2023-10-16" @default.
- W3015797184 title "The impact of tumour pH on cancer progression: strategies for clinical intervention" @default.
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