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- W3015812144 abstract "Abstract Transposable elements (TEs) comprise a major fraction of vertebrate genomes, yet little is known about their expression and regulation across tissues, and how this varies across major vertebrate lineages. We present the first comparative analysis integrating TE expression and TE regulatory pathway activity in somatic and gametic tissues for a diverse set of 12 vertebrates. We conduct simultaneous gene and TE expression analyses to characterize patterns of TE expression and TE regulation across vertebrates and examine relationships between these features. We find remarkable variation in the expression of genes involved in TE negative regulation across tissues and species, yet consistently high expression in germline tissues, particularly in testes. Most vertebrates show comparably high levels of TE regulatory pathway activity across gonadal tissues except for mammals, where reduced activity of TE regulatory pathways in ovarian tissues may be the result of lower relative germ cell densities. We also find that all vertebrate lineages examined exhibit remarkably high levels of TE-derived transcripts in somatic and gametic tissues, with recently active TE families showing higher expression in gametic tissues. Although most TE-derived transcripts originate from inactive ancient TE families (and are likely incapable of transposition), such high levels of TE-derived RNA in the cytoplasm may have secondary, unappreciated biological relevance." @default.
- W3015812144 created "2020-04-17" @default.
- W3015812144 creator A5038317733 @default.
- W3015812144 creator A5041673594 @default.
- W3015812144 creator A5054011825 @default.
- W3015812144 creator A5055872492 @default.
- W3015812144 creator A5068678015 @default.
- W3015812144 creator A5071932390 @default.
- W3015812144 date "2020-04-09" @default.
- W3015812144 modified "2023-09-26" @default.
- W3015812144 title "Vertebrate Lineages Exhibit Diverse Patterns of Transposable Element Regulation and Expression across Tissues" @default.
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