Matches in SemOpenAlex for { <https://semopenalex.org/work/W3015816552> ?p ?o ?g. }
Showing items 1 to 98 of
98
with 100 items per page.
- W3015816552 endingPage "109374" @default.
- W3015816552 startingPage "109374" @default.
- W3015816552 abstract "As a key peanut allergen, the immunoreactivity of Ara h 1 is significantly affected by protein structure which is found to be modified by various processing, although the molecular basis for this regulation has remained largely unknown. Here we explored the effect of glycosylation and glycation on the structure and antigenicity of recombinant peanut protein Ara h 1 (rAra h 1). The structural alterations were analyzed by SDS-PAGE and spectroscopic methods. ELISA, immunoblotting and degranulation test were performed to characterize the allergenicity change. Both temperature and saccharides type influenced the structure of allergic polymers formed during the glycation and glycosylation. rAra h 1 glycated by sucrose contained the IgE-binding capacity, for the intact linear epitopes were conserved during the cross linking. Our results show that glycosylation between rAra h 1 and glucosamine could be used as an effective method to lower the antigenicity of the allergen. Molecular modifications of free amino acid residues lead to the loss of both linear and conformational epitopes. Aggregates formed during glucosamine glycosylation increased the steric hindrance and destructed the intact epitopes, caused a decreased immunogenicity of rAra h 1." @default.
- W3015816552 created "2020-04-17" @default.
- W3015816552 creator A5012679798 @default.
- W3015816552 creator A5030064573 @default.
- W3015816552 creator A5040985567 @default.
- W3015816552 creator A5056840064 @default.
- W3015816552 creator A5072331448 @default.
- W3015816552 date "2020-06-01" @default.
- W3015816552 modified "2023-10-16" @default.
- W3015816552 title "Glycosylation between recombinant peanut protein Ara h 1 and glucosamine could decrease the allergenicity due to the protein aggregation" @default.
- W3015816552 cites W1975792234 @default.
- W3015816552 cites W1984491892 @default.
- W3015816552 cites W2002222714 @default.
- W3015816552 cites W2017524376 @default.
- W3015816552 cites W2129347935 @default.
- W3015816552 cites W2133827756 @default.
- W3015816552 cites W2159695216 @default.
- W3015816552 cites W2226419578 @default.
- W3015816552 cites W2522258371 @default.
- W3015816552 cites W2533501086 @default.
- W3015816552 cites W2541170535 @default.
- W3015816552 cites W2587350051 @default.
- W3015816552 cites W2800683043 @default.
- W3015816552 cites W2805910115 @default.
- W3015816552 cites W2883469375 @default.
- W3015816552 cites W2935420864 @default.
- W3015816552 doi "https://doi.org/10.1016/j.lwt.2020.109374" @default.
- W3015816552 hasPublicationYear "2020" @default.
- W3015816552 type Work @default.
- W3015816552 sameAs 3015816552 @default.
- W3015816552 citedByCount "10" @default.
- W3015816552 countsByYear W30158165522020 @default.
- W3015816552 countsByYear W30158165522021 @default.
- W3015816552 countsByYear W30158165522022 @default.
- W3015816552 countsByYear W30158165522023 @default.
- W3015816552 crossrefType "journal-article" @default.
- W3015816552 hasAuthorship W3015816552A5012679798 @default.
- W3015816552 hasAuthorship W3015816552A5030064573 @default.
- W3015816552 hasAuthorship W3015816552A5040985567 @default.
- W3015816552 hasAuthorship W3015816552A5056840064 @default.
- W3015816552 hasAuthorship W3015816552A5072331448 @default.
- W3015816552 hasConcept C104317684 @default.
- W3015816552 hasConcept C108625454 @default.
- W3015816552 hasConcept C147483822 @default.
- W3015816552 hasConcept C147990577 @default.
- W3015816552 hasConcept C170493617 @default.
- W3015816552 hasConcept C185592680 @default.
- W3015816552 hasConcept C195616568 @default.
- W3015816552 hasConcept C203014093 @default.
- W3015816552 hasConcept C207480886 @default.
- W3015816552 hasConcept C2777307526 @default.
- W3015816552 hasConcept C2777313579 @default.
- W3015816552 hasConcept C2779026604 @default.
- W3015816552 hasConcept C2780510475 @default.
- W3015816552 hasConcept C2780868878 @default.
- W3015816552 hasConcept C40767141 @default.
- W3015816552 hasConcept C55493867 @default.
- W3015816552 hasConcept C86803240 @default.
- W3015816552 hasConcept C97564808 @default.
- W3015816552 hasConceptScore W3015816552C104317684 @default.
- W3015816552 hasConceptScore W3015816552C108625454 @default.
- W3015816552 hasConceptScore W3015816552C147483822 @default.
- W3015816552 hasConceptScore W3015816552C147990577 @default.
- W3015816552 hasConceptScore W3015816552C170493617 @default.
- W3015816552 hasConceptScore W3015816552C185592680 @default.
- W3015816552 hasConceptScore W3015816552C195616568 @default.
- W3015816552 hasConceptScore W3015816552C203014093 @default.
- W3015816552 hasConceptScore W3015816552C207480886 @default.
- W3015816552 hasConceptScore W3015816552C2777307526 @default.
- W3015816552 hasConceptScore W3015816552C2777313579 @default.
- W3015816552 hasConceptScore W3015816552C2779026604 @default.
- W3015816552 hasConceptScore W3015816552C2780510475 @default.
- W3015816552 hasConceptScore W3015816552C2780868878 @default.
- W3015816552 hasConceptScore W3015816552C40767141 @default.
- W3015816552 hasConceptScore W3015816552C55493867 @default.
- W3015816552 hasConceptScore W3015816552C86803240 @default.
- W3015816552 hasConceptScore W3015816552C97564808 @default.
- W3015816552 hasFunder F4320321001 @default.
- W3015816552 hasLocation W30158165521 @default.
- W3015816552 hasOpenAccess W3015816552 @default.
- W3015816552 hasPrimaryLocation W30158165521 @default.
- W3015816552 hasRelatedWork W10307138 @default.
- W3015816552 hasRelatedWork W1899624101 @default.
- W3015816552 hasRelatedWork W1982686173 @default.
- W3015816552 hasRelatedWork W2003053548 @default.
- W3015816552 hasRelatedWork W2052027396 @default.
- W3015816552 hasRelatedWork W2079832545 @default.
- W3015816552 hasRelatedWork W2093322204 @default.
- W3015816552 hasRelatedWork W2521338293 @default.
- W3015816552 hasRelatedWork W2902749899 @default.
- W3015816552 hasRelatedWork W300186388 @default.
- W3015816552 hasVolume "127" @default.
- W3015816552 isParatext "false" @default.
- W3015816552 isRetracted "false" @default.
- W3015816552 magId "3015816552" @default.
- W3015816552 workType "article" @default.