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- W3015830230 endingPage "85" @default.
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- W3015830230 abstract "Anti-TNF biologics have achieved great success in the treatment of autoimmune diseases and have been the most selling biologics on market. However, the anti-TNF biologics have shown some disadvantages such as poor efficacy to some patients and high risk of infection and malignancies during clinical application. Current anti-TNF biologics are antibodies or antibody fragments that bind to TNF-α and subsequently block both TNF-TNFR1 and TNF-TNFR2 signaling. Transgenic animal studies indicate that TNFR1 signaling is responsible for chronic inflammation and cell apoptosis whereas TNFR2 signaling regulates tissue regeneration and inflammation. Recent studies propose to selectively inhibit TNFR1 to enhance efficacy and avoid side effects. In this review, we introduce the biology of TNF-TNFR1 and TNF-TNFR2 signaling, the advantages of selective inhibition of TNF-TNFR1 signaling and research updates on the development of selective inhibitors for TNF-TNFR1 signaling. Antibodies, small molecules and aptamers that selectively inhibit TNFR1 have showed therapeutic potential and less side effects in preclinical studies. Development of selective inhibitors for TNFR1 is a good strategy to enhance the efficacy and reduce the side effects of anti-TNF inhibitors and will be a trend for next-generation of anti-TNF inhibitors." @default.
- W3015830230 created "2020-04-17" @default.
- W3015830230 creator A5052148108 @default.
- W3015830230 creator A5076637933 @default.
- W3015830230 creator A5089881939 @default.
- W3015830230 date "2020-10-01" @default.
- W3015830230 modified "2023-10-16" @default.
- W3015830230 title "Selective inhibition of Tumor necrosis factor receptor-1 (TNFR1) for the treatment of autoimmune diseases" @default.
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- W3015830230 doi "https://doi.org/10.1016/j.cytogfr.2020.03.002" @default.
- W3015830230 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32327345" @default.
- W3015830230 hasPublicationYear "2020" @default.
- W3015830230 type Work @default.