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• W3015847085 endingPage "134953" @default.
• W3015847085 startingPage "134953" @default.
• W3015847085 abstract "Abstract Chronic epilepsy can begin with isolated early-life prolonged seizures followed by remission and the re-emergence of seizures later in life. Seizures are known to trigger a neuroinflammatory response to promote neuronal damage and increase the risk of epilepsy. We examined whether post-seizure anti-inflammatory treatment with dexamethasone after early-life seizures could decrease future seizure susceptibility and ameliorate heightened microglia activation and cell injury in response to later-life seizures. Using a “two-hit” model, early-life seizures (SZ) were induced in rats on postnatal day (P) 25 by systemic kainic acid (KA) injection followed by later-life KA at P39. P25 animals were administered anti-inflammatory drugs for 2 or 7 days after first KA exposure to inhibit seizure-induced inflammation. Hippocampal microglial activation was measured after first or second KA treatments to assay neuroinflammation, and the latency and severity of seizures to the second KA treatment were measured to determine seizure susceptibility. In situ end labeling for DNA fragmentation was used to compare KA-induced neuronal injury between treatment groups after the second KA administration. KA-SZ at P25 caused marked microglia activation within 48 hours. At P39, KA-SZ in rats without prior seizures caused a modest (2-fold) increase in microglia assayed 72 hours after KA. In contrast, microglia were markedly activated (5-fold) in response to a second KA-SZ at P39. Short-course (2 days) dexamethasone significantly decreased seizure-induced microglia activation at P25, and ameliorated the exaggerated microglia activation, cell injury, and heightened susceptibility to second-hit seizures. Although short-course dexamethasone was effective, longer term (7 days) administration of dexamethasone resulted in decreased weight gain and increased mortality in animals with or without KA-induced seizures. These data indicated that acute short-term steroid therapy after SZ could inhibit seizure-induced microglia activation and decrease the long-term damaging effects of early-life SZ. These results further implicate seizure-induced inflammation and activation of innate immunity mediated by microglia in the pathogenesis of childhood epilepsy." @default.
• W3015847085 created "2020-04-17" @default.
• W3015847085 creator A5016435346 @default.
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• W3015847085 date "2020-05-01" @default.
• W3015847085 modified "2023-09-26" @default.
• W3015847085 title "Dexamethasone after early-life seizures attenuates increased susceptibility to seizures, seizure-induced microglia activation and neuronal injury later in life" @default.
• W3015847085 cites W1584876723 @default.
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• W3015847085 cites W1969480628 @default.
• W3015847085 cites W1982487768 @default.
• W3015847085 cites W1984675794 @default.
• W3015847085 cites W1985859986 @default.
• W3015847085 cites W1987286176 @default.
• W3015847085 cites W1987864204 @default.
• W3015847085 cites W1988657178 @default.
• W3015847085 cites W1997577480 @default.
• W3015847085 cites W1997975134 @default.
• W3015847085 cites W1999410619 @default.
• W3015847085 cites W1999857229 @default.
• W3015847085 cites W2002313452 @default.
• W3015847085 cites W2004399349 @default.
• W3015847085 cites W2016931696 @default.
• W3015847085 cites W2019154598 @default.
• W3015847085 cites W2020189206 @default.
• W3015847085 cites W2020907602 @default.
• W3015847085 cites W2022592499 @default.
• W3015847085 cites W2031067551 @default.
• W3015847085 cites W2031120775 @default.
• W3015847085 cites W2032997620 @default.
• W3015847085 cites W2035299031 @default.
• W3015847085 cites W2038967954 @default.
• W3015847085 cites W2038981704 @default.
• W3015847085 cites W2041482710 @default.
• W3015847085 cites W2042829577 @default.
• W3015847085 cites W2044857503 @default.
• W3015847085 cites W2047614643 @default.
• W3015847085 cites W2048956484 @default.
• W3015847085 cites W2052770514 @default.
• W3015847085 cites W2067709897 @default.
• W3015847085 cites W2068127078 @default.
• W3015847085 cites W2068234934 @default.
• W3015847085 cites W2068779638 @default.
• W3015847085 cites W2071992832 @default.
• W3015847085 cites W2073555046 @default.
• W3015847085 cites W2083090850 @default.
• W3015847085 cites W2086595593 @default.
• W3015847085 cites W2086697336 @default.
• W3015847085 cites W2086824074 @default.
• W3015847085 cites W2087254035 @default.
• W3015847085 cites W2090883038 @default.
• W3015847085 cites W2096240982 @default.
• W3015847085 cites W2098042360 @default.
• W3015847085 cites W2098569132 @default.
• W3015847085 cites W2099416285 @default.
• W3015847085 cites W2099521343 @default.
• W3015847085 cites W2108314612 @default.
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• W3015847085 cites W2143490729 @default.
• W3015847085 cites W2144233924 @default.
• W3015847085 cites W2148898943 @default.
• W3015847085 cites W2149846553 @default.
• W3015847085 cites W2163175900 @default.
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• W3015847085 doi "https://doi.org/10.1016/j.neulet.2020.134953" @default.
• W3015847085 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32278942" @default.
• W3015847085 hasPublicationYear "2020" @default.
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