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- W3015859150 abstract "Surfactant-free emulsions were prepared by adding jojoba oil, squalane, olive oil, or glyceryl trioctanoate (medium-chain triacylglycerols: MCT) to ERI containing magnesium aluminum silicate (smectone®), and their physiochemical properties (zeta-otential, mean particle diameter, and thixotropy) were evaluated. At an oil concentration of 10%, no significant differences were observed in zeta-potentials between the various types of oil emulsions, whereas the mean particle diameters in the olive oil and MCT emulsions were smaller than those in the other oil emulsions. Measuring the hysteresis loop area of each type of emulsion revealed the markedly high thixotropies of the emulsion containing MCT at a low concentration and the olive emulsion. To facilitate the application of ERI lotion (surfactant-free emulsions containing ERI) as a component of medical drugs, we evaluated the healing effects of this water on burn wounds. A 15-month-old boy had a burn injury caused by boiling water that extended from the left forearm to the hand. An extensive skin defect was observed from the left forearm to the dorsum of the hand, and a IIb/II-degree burn was diagnosed. The burn was treated by applying ERI lotion, antibiotic/steroid combination ointment, and vitamin A/E ointment with wrap therapy. Skin color was almost normal after 74 days, and no functional impairment was observed, showing a favorable course. The burn wound completely healed without the formation of a hypertrophic or keloid scar or pigmentation. These results suggested that extensive II/III burns may be treated adequately with this topical therapy. Since surfactant agents markedly damage skin tissue sensitized by, for example, burn wounds and atopic dermatitis, surfactant-free emulsions are expected to be the new bases of drugs for external use." @default.
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- W3015859150 date "2016-09-19" @default.
- W3015859150 modified "2023-10-14" @default.
- W3015859150 title "Physicochemical Properties and Clinical Applications of Surfactant‐Free Emulsions Prepared With Electrolytic Reduction Ion Water (Eri)" @default.
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- W3015859150 doi "https://doi.org/10.1002/9781119075691.ch35" @default.
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