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- W3015864265 endingPage "63" @default.
- W3015864265 startingPage "55" @default.
- W3015864265 abstract "Murine typhus is a neglected but widespread infectious disease that results in acute fever. The immunofluorescence assay (IFA) is the gold standard to identify IgM or IgG antibodies, although there is a lack of standardization in methodologies. The objective of this review is to summarize 1) the differences in published methodologies, 2) the diagnostic cutoff titers, and 3) the justification of diagnostic cutoffs. Searches were performed by combining the following search terms: murine typhus, rickettsia typhi, immunofluorescence, IFA, and serologic with restrictions (i.e., rickettsia typhi or murine typhus, and IFA or immunofluorescence, or serologic*). The search identified 78 studies that used IFA or immunoperoxidase assay (IIP) antibody cutoffs to diagnose murine typhus, 39 of which were case series. Overall, 45 studies (57.7%) provided little to no rationale as to how the cutoff was derived. Variation was seen locally in the cutoff titers used, but a 4-fold or greater increase was often applied. The cutoffs varied depending on the antibody target. No consensus was observed in establishing a cutoff, or for a single-value diagnostic cutoff. In conclusion, there is a lack of consensus in the establishment of a single-value cutoff. Further studies will need to be executed at each distinct geographic location to identify region-specific cutoffs, while also considering background antibody levels to distinguish between healthy and infected patients." @default.
- W3015864265 created "2020-04-17" @default.
- W3015864265 creator A5021817314 @default.
- W3015864265 creator A5034097318 @default.
- W3015864265 creator A5036482181 @default.
- W3015864265 creator A5039744901 @default.
- W3015864265 creator A5056676115 @default.
- W3015864265 creator A5059054043 @default.
- W3015864265 creator A5070302572 @default.
- W3015864265 creator A5080798683 @default.
- W3015864265 date "2020-07-08" @default.
- W3015864265 modified "2023-09-26" @default.
- W3015864265 title "Selection of Diagnostic Cutoffs for Murine Typhus IgM and IgG Immunofluorescence Assay: A Systematic Review" @default.
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