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- W3015947720 abstract "Parametric positron emission tomography (PET) imaging can provide more quantitative information compared to the standard uptake value (SUV). To acquire the parametric image, a long dynamic scan over 80 mins are necessary, however, some patients with severe diseases cannot stay in a scanner such a long time or can produce bad motion artifacts during the dynamic scan. To address this issue, we propose a novel parametric PET reconstruction method using a dual injection strategy. The dual injection strategy is that the first injection of half dose at the beginning and the second injection of half dose at the middle of scan are administered, which can preserve total amount of dose. A scan is conducted after 60 mins from the first injection with a duration of total 20 mins as usually done in PET scan protocol. To estimate the parametric image, we firstly split the first and last time activity curves (TACs), and then a parametric image is estimated using partial dynamic data based on the simplified reference tissue model (SRTM). To split the TACs, a linear fitting method is used by assuming that there is no temporal metabolite changes and TAC with 20 min in the steady-state is linear. For the accurate estimation of parametric image, a penalized direct reconstruction method is proposed in which a penalty is imposed in parametric images. In brain phantom simulation, we demonstrated that the proposed method can estimate the parametric image only using 20 min acquisition." @default.
- W3015947720 created "2020-04-17" @default.
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- W3015947720 date "2019-10-01" @default.
- W3015947720 modified "2023-10-14" @default.
- W3015947720 title "Dual injection short time parametric PET image" @default.
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- W3015947720 doi "https://doi.org/10.1109/nss/mic42101.2019.9060064" @default.
- W3015947720 hasPublicationYear "2019" @default.
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