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• W3015963437 abstract "Proteins perform a spectrum of functions inside the cell, ranging from energy utilization to enzymatic activity to signaling, as well as structural and mechanical roles, among many others. Substantial research efforts throughout the years have focused on understanding these phenomena at the molecular level as well as the evolutionary processes that influenced their development. Part of these efforts include the elucidation of the fundamental principles that give shape to protein structures. Since function is encoded in the three-dimensional (3D) arrangement of proteins, identifying the principles of protein folding, structure, and dynamics has been a priority for research in protein science for many years. Inscribed on the last blackboard of Richard Feynman is the phrase “What I cannot create, I cannot understand” (1). This way of thinking has inspired scientists to not be satisfied with revealing fundamental principles but to apply them to create novel proteins with desired properties. The work of Wei et al. (2) in PNAS is a relevant example of such efforts to demonstrate understanding of biophysical principles of protein structure and dynamics by designing a protein that can change its shape under specific solution conditions.The field of protein design is challenged by the enormous space of potential protein sequences and their folds. Because of this, most efforts have been focused on studying the extant plethora of sequences and structures found in nature that were the result of millions of years of evolutionary history. Using natural proteins and their sequences as templates to engineer new proteins provides a key reduction of search space and a basis for both structural features and functional behavior. This concept has been explored successfully both experimentally and theoretically in the field of directed evolution (3) and computational template-based modeling of protein structure (4). Such has been the impact of the use of … [↵][1]1Email: faruckm{at}utdallas.edu. [1]: #xref-corresp-1-1" @default.
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• W3015963437 date "2020-04-14" @default.
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• W3015963437 title "Protein conformations à la carte, a step further in de novo protein design" @default.
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• W3015963437 doi "https://doi.org/10.1073/pnas.2004188117" @default.
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