Matches in SemOpenAlex for { <https://semopenalex.org/work/W3016027307> ?p ?o ?g. }
Showing items 1 to 79 of
79
with 100 items per page.
- W3016027307 abstract "Introduction: Several theories exist regarding the pathogenesis of posterior reversible encephalopathy syndrome (PRES). One theory suggests that PRES occurs when systemic blood pressure exceeds the upper limit of cerebral autoregulation. Endothelial dysfunction has been proposed as an alternative pathogenesis to account for PRES outside the setting of acute hypertension. This mechanism has been implicated in other conditions associated with PRES including autoimmune diseases, cytotoxic medications, sepsis, and eclampsia. The purpose of this study was to determine if COPD, a disease known to cause endothelial dysfunction, has a causative association with the development of PRES. Methods: A single center retrospective, age-matched, case-control study was performed from January 2013 to June 2019 comparing patients discharged with a primary diagnosis of PRES to a control group with acute ischemic stroke. Demographics, medical comorbidities, initial blood pressure, and clinical outcomes were compared between the two groups. For categorical variables, p-values were calculated using χ2 and Fisher’s exact tests. For continuous variables, p-values were calculated using two-sample t-tests. The effect of COPD and acute hypoxic respiratory failure on PRES status was investigated using multivariate logistic regression. Results: A total of 94 PRES subjects and 109 control subjects were included for analysis. Mean age did not differ between the two groups; however, the PRES group was more likely to be female (78.7% vs. 49.5%, p<0.001). COPD was present in 26.6% (n=25) of cases and 11% (n= 12) of controls (odds ratio 4.12, p=0.003). Occurrence of hypertension did not differ significantly between the two groups (78.0% vs 86.2%). Among patients with PRES in the setting of COPD (n=25), 60% (n=16) did not meet criteria for hypertensive emergency. Controlling for hypertensive emergency status in a multivariate logistic regression analysis, patients with COPD were 3.21 times more likely to develop PRES (p= 0.004). Conclusions: To our knowledge, very few reports of PRES in the setting of COPD have been described in the literature and no association of PRES and COPD has been defined to date. Our data support the role of COPD as a risk factor in the development of PRES." @default.
- W3016027307 created "2020-04-17" @default.
- W3016027307 creator A5015257934 @default.
- W3016027307 creator A5038458619 @default.
- W3016027307 creator A5045651335 @default.
- W3016027307 creator A5075333411 @default.
- W3016027307 creator A5078590933 @default.
- W3016027307 date "2020-02-01" @default.
- W3016027307 modified "2023-09-27" @default.
- W3016027307 title "Abstract WP220: Can’t Breathe, Can’t See, Can’t Think: Chronic Obstructive Pulmonary Disease Increases the Risk of Posterior Reversible Encephalopathy Syndrome" @default.
- W3016027307 doi "https://doi.org/10.1161/str.51.suppl_1.wp220" @default.
- W3016027307 hasPublicationYear "2020" @default.
- W3016027307 type Work @default.
- W3016027307 sameAs 3016027307 @default.
- W3016027307 citedByCount "1" @default.
- W3016027307 countsByYear W30160273072022 @default.
- W3016027307 crossrefType "journal-article" @default.
- W3016027307 hasAuthorship W3016027307A5015257934 @default.
- W3016027307 hasAuthorship W3016027307A5038458619 @default.
- W3016027307 hasAuthorship W3016027307A5045651335 @default.
- W3016027307 hasAuthorship W3016027307A5075333411 @default.
- W3016027307 hasAuthorship W3016027307A5078590933 @default.
- W3016027307 hasConcept C126322002 @default.
- W3016027307 hasConcept C126838900 @default.
- W3016027307 hasConcept C127413603 @default.
- W3016027307 hasConcept C143409427 @default.
- W3016027307 hasConcept C146304588 @default.
- W3016027307 hasConcept C156957248 @default.
- W3016027307 hasConcept C164705383 @default.
- W3016027307 hasConcept C2776780178 @default.
- W3016027307 hasConcept C2777605182 @default.
- W3016027307 hasConcept C2779234561 @default.
- W3016027307 hasConcept C2779949217 @default.
- W3016027307 hasConcept C2780645631 @default.
- W3016027307 hasConcept C2780942790 @default.
- W3016027307 hasConcept C2781276381 @default.
- W3016027307 hasConcept C54355233 @default.
- W3016027307 hasConcept C71924100 @default.
- W3016027307 hasConcept C78519656 @default.
- W3016027307 hasConcept C84393581 @default.
- W3016027307 hasConcept C86803240 @default.
- W3016027307 hasConceptScore W3016027307C126322002 @default.
- W3016027307 hasConceptScore W3016027307C126838900 @default.
- W3016027307 hasConceptScore W3016027307C127413603 @default.
- W3016027307 hasConceptScore W3016027307C143409427 @default.
- W3016027307 hasConceptScore W3016027307C146304588 @default.
- W3016027307 hasConceptScore W3016027307C156957248 @default.
- W3016027307 hasConceptScore W3016027307C164705383 @default.
- W3016027307 hasConceptScore W3016027307C2776780178 @default.
- W3016027307 hasConceptScore W3016027307C2777605182 @default.
- W3016027307 hasConceptScore W3016027307C2779234561 @default.
- W3016027307 hasConceptScore W3016027307C2779949217 @default.
- W3016027307 hasConceptScore W3016027307C2780645631 @default.
- W3016027307 hasConceptScore W3016027307C2780942790 @default.
- W3016027307 hasConceptScore W3016027307C2781276381 @default.
- W3016027307 hasConceptScore W3016027307C54355233 @default.
- W3016027307 hasConceptScore W3016027307C71924100 @default.
- W3016027307 hasConceptScore W3016027307C78519656 @default.
- W3016027307 hasConceptScore W3016027307C84393581 @default.
- W3016027307 hasConceptScore W3016027307C86803240 @default.
- W3016027307 hasIssue "Suppl_1" @default.
- W3016027307 hasLocation W30160273071 @default.
- W3016027307 hasOpenAccess W3016027307 @default.
- W3016027307 hasPrimaryLocation W30160273071 @default.
- W3016027307 hasRelatedWork W2160031265 @default.
- W3016027307 hasRelatedWork W2188772063 @default.
- W3016027307 hasRelatedWork W2314115817 @default.
- W3016027307 hasRelatedWork W2516638804 @default.
- W3016027307 hasRelatedWork W2531421384 @default.
- W3016027307 hasRelatedWork W2792024821 @default.
- W3016027307 hasRelatedWork W2805360124 @default.
- W3016027307 hasRelatedWork W2968679091 @default.
- W3016027307 hasRelatedWork W4200168490 @default.
- W3016027307 hasRelatedWork W4210361826 @default.
- W3016027307 hasVolume "51" @default.
- W3016027307 isParatext "false" @default.
- W3016027307 isRetracted "false" @default.
- W3016027307 magId "3016027307" @default.
- W3016027307 workType "article" @default.