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- W3016055372 abstract "Campylobacter jejuni, a foodborne pathogen, is one of the most common bacterial causes of gastroenteritis in the world. Undercooked poultry, raw (unpasteurized) dairy products, untreated water, and contaminated produce are the most common sources associated with infection. C. jejuni establishes a niche in the gut by adhering to and invading epithelial cells, which results in diarrhea with blood and mucus in the stool. The process of colonization is mediated, in part, by surface-exposed molecules (adhesins) that bind directly to host cell ligands or the extracellular matrix (ECM) surrounding cells. In this review, we introduce the known and putative adhesins of the foodborne pathogen C. jejuni. We then focus our discussion on two C. jejuni Microbial Surface Components Recognizing Adhesive Matrix Molecule(s) (MSCRAMMs), termed CadF and FlpA, which have been demonstrated to contribute to C. jejuni colonization and pathogenesis. In vitro studies have determined that these two surface-exposed proteins bind to the ECM glycoprotein fibronectin (FN). In vivo studies have shown that cadF and flpA mutants exhibit impaired colonization of chickens compared to the wild-type strain. Additional studies have revealed that CadF and FlpA stimulate epithelial cell signaling pathways necessary for cell invasion. Interestingly, CadF and FlpA have distinct FN-binding domains, suggesting that the functions of these proteins are non-redundant. In summary, the binding of FN by C. jejuni CadF and FlpA adhesins has been demonstrated to contribute to adherence, invasion, and cell signaling." @default.
- W3016055372 created "2020-04-17" @default.
- W3016055372 creator A5002318189 @default.
- W3016055372 creator A5003298423 @default.
- W3016055372 creator A5016201669 @default.
- W3016055372 creator A5070168697 @default.
- W3016055372 date "2020-04-09" @default.
- W3016055372 modified "2023-10-17" @default.
- W3016055372 title "Taking Control: Campylobacter jejuni Binding to Fibronectin Sets the Stage for Cellular Adherence and Invasion" @default.
- W3016055372 cites W140614393 @default.
- W3016055372 cites W1559086192 @default.
- W3016055372 cites W171398818 @default.
- W3016055372 cites W1744198372 @default.
- W3016055372 cites W1837686887 @default.
- W3016055372 cites W1849301422 @default.
- W3016055372 cites W1855872860 @default.
- W3016055372 cites W1892640292 @default.
- W3016055372 cites W1895825421 @default.
- W3016055372 cites W1965202893 @default.
- W3016055372 cites W1968863528 @default.
- W3016055372 cites W1970364970 @default.
- W3016055372 cites W1971447551 @default.
- W3016055372 cites W1972167942 @default.
- W3016055372 cites W1973396885 @default.
- W3016055372 cites W1975189581 @default.
- W3016055372 cites W1976642928 @default.
- W3016055372 cites W1977075078 @default.
- W3016055372 cites W1984295003 @default.
- W3016055372 cites W1990644839 @default.
- W3016055372 cites W1991359833 @default.
- W3016055372 cites W1991998717 @default.
- W3016055372 cites W1993607801 @default.
- W3016055372 cites W1995572199 @default.
- W3016055372 cites W1997345929 @default.
- W3016055372 cites W1997681612 @default.
- W3016055372 cites W2002695399 @default.
- W3016055372 cites W2003545333 @default.
- W3016055372 cites W2003703104 @default.
- W3016055372 cites W2005523568 @default.
- W3016055372 cites W2010172515 @default.
- W3016055372 cites W2011276624 @default.
- W3016055372 cites W2017442666 @default.
- W3016055372 cites W2017667097 @default.
- W3016055372 cites W2017702837 @default.
- W3016055372 cites W2023171524 @default.
- W3016055372 cites W2024295154 @default.
- W3016055372 cites W2025609605 @default.
- W3016055372 cites W2029009312 @default.
- W3016055372 cites W2034488459 @default.
- W3016055372 cites W2039553601 @default.
- W3016055372 cites W2044676634 @default.
- W3016055372 cites W2044895919 @default.
- W3016055372 cites W2045295282 @default.
- W3016055372 cites W2049170131 @default.
- W3016055372 cites W2053680232 @default.
- W3016055372 cites W2054115369 @default.
- W3016055372 cites W2058042902 @default.
- W3016055372 cites W2061671189 @default.
- W3016055372 cites W2066512944 @default.
- W3016055372 cites W2072558376 @default.
- W3016055372 cites W2078057379 @default.
- W3016055372 cites W2089039697 @default.
- W3016055372 cites W2091984766 @default.
- W3016055372 cites W2092731808 @default.
- W3016055372 cites W2094007386 @default.
- W3016055372 cites W2094738551 @default.
- W3016055372 cites W2095324004 @default.
- W3016055372 cites W2098069668 @default.
- W3016055372 cites W2098080881 @default.
- W3016055372 cites W2102318886 @default.
- W3016055372 cites W2103442138 @default.
- W3016055372 cites W2106975189 @default.
- W3016055372 cites W2107508284 @default.
- W3016055372 cites W2108770100 @default.
- W3016055372 cites W2114346444 @default.
- W3016055372 cites W2114534122 @default.
- W3016055372 cites W2117789346 @default.
- W3016055372 cites W2127135538 @default.
- W3016055372 cites W2127223440 @default.
- W3016055372 cites W2127858913 @default.
- W3016055372 cites W2128644132 @default.
- W3016055372 cites W2130320320 @default.
- W3016055372 cites W2130610744 @default.
- W3016055372 cites W2135925002 @default.
- W3016055372 cites W2136878333 @default.
- W3016055372 cites W2139310472 @default.
- W3016055372 cites W2140598855 @default.
- W3016055372 cites W2142250977 @default.
- W3016055372 cites W2142546334 @default.
- W3016055372 cites W2144754611 @default.
- W3016055372 cites W2145865573 @default.
- W3016055372 cites W2146453842 @default.
- W3016055372 cites W2149166586 @default.
- W3016055372 cites W2150626270 @default.
- W3016055372 cites W2151933077 @default.
- W3016055372 cites W2153824781 @default.
- W3016055372 cites W2153936454 @default.
- W3016055372 cites W2154304237 @default.
- W3016055372 cites W2154921479 @default.
- W3016055372 cites W2155583117 @default.