Matches in SemOpenAlex for { <https://semopenalex.org/work/W3016063745> ?p ?o ?g. }
- W3016063745 abstract "Abstract Alzheimer’s disease (AD) is a chronic neurodegenerative disease with significant financial costs and negative impacts on quality of life. Psychotic symptoms, i.e., the presence of delusions and/or hallucinations, is a frequent complication of AD. About 50% of AD patients will develop psychotic symptoms (AD with Psychosis, or AD + P) and these patients will experience an even more rapid cognitive decline than AD patients without psychosis (AD-P). In a previous analysis on medication records of 776 AD patients, we had shown that use of Vitamin D was associated with delayed time to psychosis in AD patients and Vitamin D was used more by AD-P than AD + P patients. To explore the potential molecular mechanism behind our findings, we applied systems pharmacology approaches to investigate the crosstalk between AD and psychosis. Specifically, we built protein-protein interaction (PPI) networks with proteins encoded by AD- and psychosis-related genes and Vitamin D-perturbed genes. Using network analysis we identified several high-impact genes, including NOTCH4, COMT, CACNA1C and DRD3 which are related to calcium homeostasis. The new findings highlight the key role of calcium-related signaling pathways in AD + P development and may provide a new direction and facilitate hypothesis generation for future drug development." @default.
- W3016063745 created "2020-04-17" @default.
- W3016063745 creator A5020691605 @default.
- W3016063745 creator A5037889949 @default.
- W3016063745 creator A5084605837 @default.
- W3016063745 creator A5088688660 @default.
- W3016063745 date "2020-04-09" @default.
- W3016063745 modified "2023-10-02" @default.
- W3016063745 title "Network Systems Pharmacology-Based Mechanism Study on the Beneficial Effects of Vitamin D against Psychosis in Alzheimer’s Disease" @default.
- W3016063745 cites W1559492976 @default.
- W3016063745 cites W1585687822 @default.
- W3016063745 cites W1591177635 @default.
- W3016063745 cites W1600879246 @default.
- W3016063745 cites W1965917470 @default.
- W3016063745 cites W1971937094 @default.
- W3016063745 cites W1972012028 @default.
- W3016063745 cites W1980298259 @default.
- W3016063745 cites W1983284897 @default.
- W3016063745 cites W1987350568 @default.
- W3016063745 cites W1989178832 @default.
- W3016063745 cites W1994593489 @default.
- W3016063745 cites W1996014455 @default.
- W3016063745 cites W1998323848 @default.
- W3016063745 cites W2011301426 @default.
- W3016063745 cites W2012227436 @default.
- W3016063745 cites W2013753233 @default.
- W3016063745 cites W2020301095 @default.
- W3016063745 cites W2020616753 @default.
- W3016063745 cites W2025459091 @default.
- W3016063745 cites W2034734184 @default.
- W3016063745 cites W2035020452 @default.
- W3016063745 cites W2037250700 @default.
- W3016063745 cites W2039143811 @default.
- W3016063745 cites W2047940964 @default.
- W3016063745 cites W2057651195 @default.
- W3016063745 cites W2060106998 @default.
- W3016063745 cites W2065881899 @default.
- W3016063745 cites W2073554507 @default.
- W3016063745 cites W2079662917 @default.
- W3016063745 cites W2091570747 @default.
- W3016063745 cites W2091660125 @default.
- W3016063745 cites W2094045717 @default.
- W3016063745 cites W2098349177 @default.
- W3016063745 cites W2099970772 @default.
- W3016063745 cites W2101357408 @default.
- W3016063745 cites W2101580881 @default.
- W3016063745 cites W2103118693 @default.
- W3016063745 cites W2105924489 @default.
- W3016063745 cites W2113613985 @default.
- W3016063745 cites W2113709916 @default.
- W3016063745 cites W2119139647 @default.
- W3016063745 cites W2123633329 @default.
- W3016063745 cites W2127205775 @default.
- W3016063745 cites W2133978035 @default.
- W3016063745 cites W2144014661 @default.
- W3016063745 cites W2149732522 @default.
- W3016063745 cites W2157997136 @default.
- W3016063745 cites W2163302570 @default.
- W3016063745 cites W2171707538 @default.
- W3016063745 cites W2528415721 @default.
- W3016063745 cites W2598146495 @default.
- W3016063745 cites W2790770149 @default.
- W3016063745 cites W2901303766 @default.
- W3016063745 cites W2923874815 @default.
- W3016063745 cites W2951529834 @default.
- W3016063745 cites W3136918052 @default.
- W3016063745 cites W4237095724 @default.
- W3016063745 cites W4294216483 @default.
- W3016063745 doi "https://doi.org/10.1038/s41598-020-63021-8" @default.
- W3016063745 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7145835" @default.
- W3016063745 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32273551" @default.
- W3016063745 hasPublicationYear "2020" @default.
- W3016063745 type Work @default.
- W3016063745 sameAs 3016063745 @default.
- W3016063745 citedByCount "7" @default.
- W3016063745 countsByYear W30160637452021 @default.
- W3016063745 countsByYear W30160637452022 @default.
- W3016063745 countsByYear W30160637452023 @default.
- W3016063745 crossrefType "journal-article" @default.
- W3016063745 hasAuthorship W3016063745A5020691605 @default.
- W3016063745 hasAuthorship W3016063745A5037889949 @default.
- W3016063745 hasAuthorship W3016063745A5084605837 @default.
- W3016063745 hasAuthorship W3016063745A5088688660 @default.
- W3016063745 hasBestOaLocation W30160637451 @default.
- W3016063745 hasConcept C111472728 @default.
- W3016063745 hasConcept C118552586 @default.
- W3016063745 hasConcept C120665830 @default.
- W3016063745 hasConcept C121332964 @default.
- W3016063745 hasConcept C124490489 @default.
- W3016063745 hasConcept C126322002 @default.
- W3016063745 hasConcept C138885662 @default.
- W3016063745 hasConcept C15744967 @default.
- W3016063745 hasConcept C169760540 @default.
- W3016063745 hasConcept C169822122 @default.
- W3016063745 hasConcept C2779134260 @default.
- W3016063745 hasConcept C2779727114 @default.
- W3016063745 hasConcept C2780035454 @default.
- W3016063745 hasConcept C60644358 @default.
- W3016063745 hasConcept C64903051 @default.
- W3016063745 hasConcept C71924100 @default.