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- W3016085648 endingPage "104315" @default.
- W3016085648 startingPage "104315" @default.
- W3016085648 abstract "Salmonella strains are responsible for a huge mortality rate through foodborne ailment in the world that necessitated the discovery of novel drugs and vaccines. Essential hypothetical proteins (EHPs), whose structures and functions were previously unknown, could serve as potential therapeutic and vaccine targets. Antivirulence therapy shall emerge as a superior therapeutic approach that uses virulence factors as drug targets. This study annotated the biological functions of 96 out of total 106 essential hypothetical proteins in five strains of Salmonella and classified into nine important protein categories. 34 virulence factors were predicted among the EHPs, out of which, 11 were identified to be pathogen specific potential drug targets for antivirulence therapy. These targets were non-homologous to both human and gut microbiota proteome to avoid cross-reactivity with them. Seven identified targets had druggable property, while the rest four targets were novel targets. Four identified targets (DEG10320148, DEG10110027, DEG10110040 and DEG10110142) had antigenic properties and were further classified as: two membrane-bound Lipid-binding transmembrane proteins, a Zinc-binding membrane protein and an extracellular glycosylase. These targets could be potentially used for the development of subunit vaccines. The study further identified 11 highly conserved and exposed epitope sequences from these 4 vaccine targets. The three-dimensional structures of the vaccine targets were also elucidated along with highlighting the conformation of the epitopes. This study identified potential therapeutic targets for antivirulence therapy against Salmonella. It would therefore instigate in novel drug designing as well as provide important leads to new Salmonella vaccine development." @default.
- W3016085648 created "2020-04-17" @default.
- W3016085648 creator A5001282764 @default.
- W3016085648 creator A5025224920 @default.
- W3016085648 creator A5047715347 @default.
- W3016085648 creator A5056690228 @default.
- W3016085648 date "2020-09-01" @default.
- W3016085648 modified "2023-10-14" @default.
- W3016085648 title "Identification of novel therapeutic target and epitopes through proteome mining from essential hypothetical proteins in Salmonella strains: An In silico approach towards antivirulence therapy and vaccine development" @default.
- W3016085648 cites W106876885 @default.
- W3016085648 cites W1499050330 @default.
- W3016085648 cites W1553348964 @default.
- W3016085648 cites W1592197664 @default.
- W3016085648 cites W1661084202 @default.
- W3016085648 cites W1836520876 @default.
- W3016085648 cites W1894856070 @default.
- W3016085648 cites W1919642295 @default.
- W3016085648 cites W1936339737 @default.
- W3016085648 cites W1964767165 @default.
- W3016085648 cites W1964907148 @default.
- W3016085648 cites W1965517743 @default.
- W3016085648 cites W1968855741 @default.
- W3016085648 cites W1969724909 @default.
- W3016085648 cites W1973310873 @default.
- W3016085648 cites W1975610860 @default.
- W3016085648 cites W1975875968 @default.
- W3016085648 cites W1980046147 @default.
- W3016085648 cites W1981108131 @default.
- W3016085648 cites W1981264193 @default.
- W3016085648 cites W1982298524 @default.
- W3016085648 cites W1984932018 @default.
- W3016085648 cites W1986191025 @default.
- W3016085648 cites W2000502273 @default.
- W3016085648 cites W2006025024 @default.
- W3016085648 cites W2017681516 @default.
- W3016085648 cites W2018385789 @default.
- W3016085648 cites W2022305349 @default.
- W3016085648 cites W2037312364 @default.
- W3016085648 cites W2038536960 @default.
- W3016085648 cites W2039095343 @default.
- W3016085648 cites W2041685603 @default.
- W3016085648 cites W2045019711 @default.
- W3016085648 cites W2045585923 @default.
- W3016085648 cites W2045729458 @default.
- W3016085648 cites W2050394160 @default.
- W3016085648 cites W2053493806 @default.
- W3016085648 cites W2055043387 @default.
- W3016085648 cites W2063562746 @default.
- W3016085648 cites W2067964678 @default.
- W3016085648 cites W2073104221 @default.
- W3016085648 cites W2077899989 @default.
- W3016085648 cites W2079791488 @default.
- W3016085648 cites W2083316892 @default.
- W3016085648 cites W2097546936 @default.
- W3016085648 cites W2097874743 @default.
- W3016085648 cites W2102367710 @default.
- W3016085648 cites W2103312429 @default.
- W3016085648 cites W2107247090 @default.
- W3016085648 cites W2107777445 @default.
- W3016085648 cites W2113140044 @default.
- W3016085648 cites W2122741036 @default.
- W3016085648 cites W2127739733 @default.
- W3016085648 cites W2130479394 @default.
- W3016085648 cites W2132820240 @default.
- W3016085648 cites W2136723682 @default.
- W3016085648 cites W2138271600 @default.
- W3016085648 cites W2143250705 @default.
- W3016085648 cites W2147153627 @default.
- W3016085648 cites W2149218328 @default.
- W3016085648 cites W2151215280 @default.
- W3016085648 cites W2153878038 @default.
- W3016085648 cites W2156345326 @default.
- W3016085648 cites W2162792752 @default.
- W3016085648 cites W2224056471 @default.
- W3016085648 cites W2376573086 @default.
- W3016085648 cites W2474401221 @default.
- W3016085648 cites W2510043632 @default.
- W3016085648 cites W2517879681 @default.
- W3016085648 cites W2542470497 @default.
- W3016085648 cites W2564003941 @default.
- W3016085648 cites W2564788005 @default.
- W3016085648 cites W2568502991 @default.
- W3016085648 cites W2589379890 @default.
- W3016085648 cites W2620385970 @default.
- W3016085648 cites W2708317524 @default.
- W3016085648 cites W2749140659 @default.
- W3016085648 cites W2766607092 @default.
- W3016085648 cites W2767331836 @default.
- W3016085648 cites W2797848594 @default.
- W3016085648 cites W2799828084 @default.
- W3016085648 cites W2800370037 @default.
- W3016085648 cites W2802312498 @default.
- W3016085648 cites W2807288347 @default.
- W3016085648 cites W2914280503 @default.
- W3016085648 cites W2924547297 @default.
- W3016085648 cites W3017241545 @default.
- W3016085648 cites W4211002175 @default.
- W3016085648 cites W4232088799 @default.