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• W3016087356 abstract "Dimension reduction of high-dimensional microbiome data facilitates subsequent analysis such as regression and clustering. Most existing reduction methods cannot fully accommodate the special features of the data such as count-valued and excessive zero reads. We propose a zero-inflated Poisson factor analysis (ZIPFA) model in this article. The model assumes that microbiome absolute abundance data follow zero-inflated Poisson distributions with library size as offset and Poisson rates negatively related to the inflated zero occurrences. The latent parameters of the model form a low-rank matrix consisting of interpretable loadings and low-dimensional scores which can be used for further analyses. We develop an efficient and robust expectation-maximization (EM) algorithm for parameter estimation. We demonstrate the efficacy of the proposed method using comprehensive simulation studies. The application to the Oral Infections, Glucose Intolerance and Insulin Resistance Study (ORIGINS) provides valuable insights into the relation between subgingival microbiome and periodontal disease." @default.
• W3016087356 created "2020-04-17" @default.
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• W3016087356 date "2020-05-04" @default.
• W3016087356 modified "2023-10-09" @default.
• W3016087356 title "Zero‐inflated Poisson factor model with application to microbiome read counts" @default.
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• W3016087356 doi "https://doi.org/10.1111/biom.13272" @default.
• W3016087356 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7594114" @default.
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