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• W3016140744 endingPage "4748" @default.
• W3016140744 startingPage "4737" @default.
• W3016140744 abstract "Cell-free DNA (cfDNA) has pioneered the development of noninvasive prenatal testing and liquid biopsy, its emerging applications include organ transplantation, autoimmune diseases, and many other disorders; size profile of cfDNA is a crucial biological property and is essential for its clinical applications. Therefore, a thorough mastery of the characteristic and potential applications of cfDNA size profile is needed. Methods: Based on the recent researches, we summarized the size profile of cfDNA in pregnant women, tumor patients, transplant recipients and systemic lupus erythematosus (SLE) patients to explore the common features. We also concluded the applications of size profile in pre-analytical phases, analytical phases for novel assays, and preparation of quality control materials (QCMs). Results: The size profile of cfDNA shared common features in different populations, and was distributed as a ladder pattern with a dominant peak at ~166 bp. However, cfDNA entailed slightly discrepant characteristics due to specific tissues of origin. The dominant peaks of fetal and maternal cfDNA fragments in pregnant women were at 143 bp and 166 bp, respectively. The plasma cfDNA in tumor patients, transplant recipients, and SLE patients had a peak of around 166 bp. In pre-analytical phases, size profile served as a vital indicator to judge the eligibility of specimens, thus ensuring the successful implementation of assays. More importantly, the size profile had the potential to enrich short fragments, calculate fetal fraction, detect fetal abnormalities, predict tumor progress in analytical phase and to guide the preparation of QCMs. Conclusions: Our finding summarized the characteristics and potential applications of cfDNA size profile, providing clinical researchers with novel assays by the extensive application of cfDNA." @default.
• W3016140744 created "2020-04-17" @default.
• W3016140744 creator A5029943131 @default.
• W3016140744 creator A5038084459 @default.
• W3016140744 creator A5038934949 @default.
• W3016140744 creator A5080184683 @default.
• W3016140744 date "2020-01-01" @default.
• W3016140744 modified "2023-09-27" @default.
• W3016140744 title "Size profile of cell-free DNA: A beacon guiding the practice and innovation of clinical testing" @default.
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• W3016140744 doi "https://doi.org/10.7150/thno.42565" @default.
• W3016140744 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7163439" @default.
• W3016140744 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32308746" @default.

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