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- W3016169593 abstract "Abstract Although group 3 innate lymphoid cells (ILC3s) are efficient inducers of T cell responses in the spleen, they fail to induce CD4 + T cell proliferation in the gut. The signals regulating ILC3-T cell responses remain unknown. Here, we show that transcripts associated with MHC II antigen presentation are down-modulated in intestinal natural cytotoxicity receptor (NCR) − ILC3s. Further data implicate microbiota-induced IL-23 as a crucial signal for reversible silencing of MHC II in ILC3s, thereby reducing the capacity of ILC3s to present antigen to T cells in the intestinal mucosa. Moreover, IL-23-mediated MHC II suppression is dependent on mTORC1 and STAT3 phosphorylation in NCR − ILC3s. By contrast, splenic interferon-γ induces MHC II expression and CD4 + T cell stimulation by NCR − ILC3s. Our results thus identify biological circuits for tissue-specific regulation of ILC3-dependent T cell responses. These pathways may have implications for inducing or silencing T cell responses in human diseases." @default.
- W3016169593 created "2020-04-17" @default.
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- W3016169593 date "2020-04-14" @default.
- W3016169593 modified "2023-10-03" @default.
- W3016169593 title "Microbiota-induced tissue signals regulate ILC3-mediated antigen presentation" @default.
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- W3016169593 doi "https://doi.org/10.1038/s41467-020-15612-2" @default.
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