Matches in SemOpenAlex for { <https://semopenalex.org/work/W3016169901> ?p ?o ?g. }
Showing items 1 to 87 of
87
with 100 items per page.
- W3016169901 endingPage "1893" @default.
- W3016169901 startingPage "1888" @default.
- W3016169901 abstract "A multioperation, continuous-flow platform for the synthesis of tramadol, ranging from gram to decagram quantities, is described. The platform is segmented into two halves allowing for a single operator to modulate between preparation of the intermediate by Mannich addition or complete the fully concatenated synthesis. All purification operations are incorporated in-line for the Mannich reaction. ‘Flash’ reactivity between meta-methoxyphenyl magnesium bromide and the Mannich product was controlled with a static helical mixer and tested with a combination of flow and batch-based and factorial evaluations. These efforts culminated in a rapid production rate of tramadol (13.7 g°h–1) sustained over 56 reactor volumes. A comparison of process metrics including E-Factor, production rate, and space-time yield are used to contextualize the developed platform with respect to established engineering and synthetic methods for making tramadol." @default.
- W3016169901 created "2020-04-17" @default.
- W3016169901 creator A5034072746 @default.
- W3016169901 creator A5034963384 @default.
- W3016169901 creator A5051000767 @default.
- W3016169901 creator A5090442721 @default.
- W3016169901 date "2020-04-09" @default.
- W3016169901 modified "2023-09-25" @default.
- W3016169901 title "Continuous-Flow Synthesis of Tramadol from Cyclohexanone" @default.
- W3016169901 cites W2045730050 @default.
- W3016169901 cites W2070276075 @default.
- W3016169901 cites W2126451255 @default.
- W3016169901 cites W2152413572 @default.
- W3016169901 cites W2536985330 @default.
- W3016169901 cites W2614859841 @default.
- W3016169901 cites W2747202316 @default.
- W3016169901 cites W2776520481 @default.
- W3016169901 cites W2893512291 @default.
- W3016169901 cites W2917409746 @default.
- W3016169901 cites W2952131313 @default.
- W3016169901 cites W2981551380 @default.
- W3016169901 doi "https://doi.org/10.1055/s-0039-1690884" @default.
- W3016169901 hasPublicationYear "2020" @default.
- W3016169901 type Work @default.
- W3016169901 sameAs 3016169901 @default.
- W3016169901 citedByCount "8" @default.
- W3016169901 countsByYear W30161699012020 @default.
- W3016169901 countsByYear W30161699012021 @default.
- W3016169901 countsByYear W30161699012022 @default.
- W3016169901 countsByYear W30161699012023 @default.
- W3016169901 crossrefType "journal-article" @default.
- W3016169901 hasAuthorship W3016169901A5034072746 @default.
- W3016169901 hasAuthorship W3016169901A5034963384 @default.
- W3016169901 hasAuthorship W3016169901A5051000767 @default.
- W3016169901 hasAuthorship W3016169901A5090442721 @default.
- W3016169901 hasConcept C119857082 @default.
- W3016169901 hasConcept C121332964 @default.
- W3016169901 hasConcept C134121241 @default.
- W3016169901 hasConcept C161790260 @default.
- W3016169901 hasConcept C16469947 @default.
- W3016169901 hasConcept C169222746 @default.
- W3016169901 hasConcept C178790620 @default.
- W3016169901 hasConcept C185592680 @default.
- W3016169901 hasConcept C206139338 @default.
- W3016169901 hasConcept C21951064 @default.
- W3016169901 hasConcept C2776300020 @default.
- W3016169901 hasConcept C2780450521 @default.
- W3016169901 hasConcept C2780640045 @default.
- W3016169901 hasConcept C41008148 @default.
- W3016169901 hasConcept C97355855 @default.
- W3016169901 hasConceptScore W3016169901C119857082 @default.
- W3016169901 hasConceptScore W3016169901C121332964 @default.
- W3016169901 hasConceptScore W3016169901C134121241 @default.
- W3016169901 hasConceptScore W3016169901C161790260 @default.
- W3016169901 hasConceptScore W3016169901C16469947 @default.
- W3016169901 hasConceptScore W3016169901C169222746 @default.
- W3016169901 hasConceptScore W3016169901C178790620 @default.
- W3016169901 hasConceptScore W3016169901C185592680 @default.
- W3016169901 hasConceptScore W3016169901C206139338 @default.
- W3016169901 hasConceptScore W3016169901C21951064 @default.
- W3016169901 hasConceptScore W3016169901C2776300020 @default.
- W3016169901 hasConceptScore W3016169901C2780450521 @default.
- W3016169901 hasConceptScore W3016169901C2780640045 @default.
- W3016169901 hasConceptScore W3016169901C41008148 @default.
- W3016169901 hasConceptScore W3016169901C97355855 @default.
- W3016169901 hasFunder F4320332180 @default.
- W3016169901 hasIssue "19" @default.
- W3016169901 hasLocation W30161699011 @default.
- W3016169901 hasOpenAccess W3016169901 @default.
- W3016169901 hasPrimaryLocation W30161699011 @default.
- W3016169901 hasRelatedWork W1975289204 @default.
- W3016169901 hasRelatedWork W1992348337 @default.
- W3016169901 hasRelatedWork W2047888616 @default.
- W3016169901 hasRelatedWork W2065557283 @default.
- W3016169901 hasRelatedWork W2142640210 @default.
- W3016169901 hasRelatedWork W2356540558 @default.
- W3016169901 hasRelatedWork W2375547858 @default.
- W3016169901 hasRelatedWork W2951467745 @default.
- W3016169901 hasRelatedWork W2952059417 @default.
- W3016169901 hasRelatedWork W2972846635 @default.
- W3016169901 hasVolume "31" @default.
- W3016169901 isParatext "false" @default.
- W3016169901 isRetracted "false" @default.
- W3016169901 magId "3016169901" @default.
- W3016169901 workType "article" @default.