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• W3016174557 abstract "ABSTRACT In this study, we demonstrate that mouse DLX2 binds to the Olig2 gene locus in mouse embryonic forebrain in vivo . We further confirm the specificity and the transcriptional repressive effect of the binding in vitro . Furthermore, loss of Dlx1/2 function leads to increased Olig2 expression in the ventral embryonic mouse forebrain in vivo . As well, we demonstrate that chicken DLX1 binds to one chicken Olig2 gene domain in vitro , and overexpression of Dlx1 is sufficient to repress Olig2 expression in the developing chicken forebrain in ovo . Chicken DLX1 with a mutation eliminating its DNA binding ability is unable to bind to the Olig2 probe in vitro , and abrogates its repressive function on Olig2 expression in ovo . Our results establish that Dlx1/2 is both necessary and sufficient to repress oligodendrocyte specification mediated via direct transcriptional inhibition of Olig2 expression in the developing vertebrate forebrain." @default.
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• W3016174557 date "2020-04-10" @default.
• W3016174557 modified "2023-09-24" @default.
• W3016174557 title "Distal-less genes<i>Dlx1/Dlx2</i>repress oligodendrocyte genesis through transcriptional inhibition of<i>Olig2</i>expression in the developing vertebrate forebrain" @default.
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• W3016174557 doi "https://doi.org/10.1101/2020.04.09.012385" @default.
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