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• W3016231625 abstract "The COVID-19 pandemic has placed health care systems worldwide under strain unprecedented in recent times. Personal protective equipment (PPE) shortages in many countries have led to increasing reports on mainstream and social media (including the widely publicized #GetMePPE movement on Twitter) of improvised methods featuring household items. One such setup featured the use of a transparent plastic bag placed around heads of practitioners with an airtight seal around the neck to protect against aerosolized droplets during endotracheal intubation, in lieu of goggles and an N95 respirator (Figure 1). This allows the operator to rebreathe his expired (but hopefully uncontaminated) air for a limited time during the procedure. Although this might offer better protection from infection than current Centers for Disease Control and Prevention recommendations for homemade cloth masks in situations of last resort, it also introduces risks of hypoxia and hypercarbia due to rebreathing (1MacIntyre C.R. Seale H. Dung T.C. et al.A cluster randomised trial of cloth masks compared with medical masks in healthcare workers.BMJ Open. 2015; 5: e006577Crossref PubMed Scopus (291) Google Scholar,2Callaham M. Hypoxic hazards of traditional paper bag rebreathing in hyperventilating patients.Ann Emerg Med. 1989; 18: 622-628Abstract Full Text PDF PubMed Scopus (34) Google Scholar). Experiments on rebreathing have previously been reported, but were performed under sufficiently different conditions (breathing directly into a bag placed around the mouth) that extrapolation of results to the above setup might not be meaningful (2Callaham M. Hypoxic hazards of traditional paper bag rebreathing in hyperventilating patients.Ann Emerg Med. 1989; 18: 622-628Abstract Full Text PDF PubMed Scopus (34) Google Scholar,3Obuchi T. Shimamura S. Miyahara N. et al.CO2 retention: the key to stopping hiccups.Clin Respir J. 2018; 12: 2340-2345Crossref PubMed Scopus (10) Google Scholar). To study the limitations of the described setup, two of the authors (one male and one female, in their thirties with no prior cardiorespiratory disease) volunteered to have 70-L plastic bags prefilled with environmental air placed around their heads with an airtight seal around their necks. Heart rate and rhythm, respiratory rate, and oxygen saturation were monitored. The gas composition in the bag (fraction of inspired oxygen and carbon dioxide partial pressure) was continuously sampled with the gas analyzer module of an anesthesia machine (M-CAIOV, Datex Ohmeda, General Electric Company, Boston, MA) via a sampling line inserted into the bag. Each run was aborted when symptoms experienced were felt to be significant enough to impair the capacity to safely carry out a medical procedure, such as endotracheal intubation. At termination, time elapsed and subject’s end-tidal carbon dioxide partial pressure were recorded. The experiments were then repeated, with the same bags prefilled with oxygen prior to use (results in Table 1).Table 1Physiological Parameters and Bag Gas Composition During Rebreathing ExperimentBag Prefilled with:AirOxygenSubject ASubject BSubject ASubject BTime ElapsedBag PCO2 (mm Hg)Bag FiO2 (%)Bag PCO2 (mm Hg)Bag FiO2 (%)Bag PCO2 (mm Hg)Bag FiO2 (%)Bag PCO2 (mm Hg)Bag FiO2 (%)1 min23181219156411712 min32162217286118693 min48142916356026644 min51123415425831605 min5510475635576 min515542547 min55538 min5852Subject's EtCO2 at termination (mm Hg)59506752Subject's SpO2 at termination (%)949898100Time elapsed at termination (m:s)5:204:408:376:31Mean time elapsed at termination (m:s)5:007:34PCO2 = partial pressure of carbon dioxide; FiO2 = fraction of inspired oxygen; EtCO2 = partial pressure of end-tidal carbon dioxide; SpO2 = peripheral arterial oxygen saturation.Subject A: Male, 38 years old, 184 cm, 80 kg.Subject B: Female, 36 years old, 159 cm, 46 kg. Open table in a new tab PCO2 = partial pressure of carbon dioxide; FiO2 = fraction of inspired oxygen; EtCO2 = partial pressure of end-tidal carbon dioxide; SpO2 = peripheral arterial oxygen saturation. Subject A: Male, 38 years old, 184 cm, 80 kg. Subject B: Female, 36 years old, 159 cm, 46 kg. In all cases, bag partial pressures of carbon dioxide rose quickly, resulting in significant hypercarbia at termination. This accounted for the breathlessness (the primary symptom that resulted in termination of the experiments), anxiety, and distress that both authors reported nearing the end of each run. Overall, the mean duration tolerated was short, although longer when bags were prefilled with oxygen (5 min vs 7.5 min). Only the environment in bags prefilled with air became hypoxic, although no oxygen desaturation below 94% occurred. These findings are consistent with our understanding of physiology, with hypercarbia being the major contributor of dyspnea and limiting factor for tolerance in this situation, secondarily compounded by hypoxia (4Nishino T. Dyspnoea: underlying mechanisms and treatment.Br J Anaesth. 2011; 106: 463-474Abstract Full Text Full Text PDF PubMed Scopus (63) Google Scholar). Our study demonstrates that users under real-life conditions will be under time pressure to complete all but the shortest procedures and may be subjected to distressing physiological and psychological effects during more prolonged use. They also may risk hypoxia (especially if the bag is not prefilled with oxygen) and serious carbon dioxide toxicity in situations where the option to abort an unexpectedly prolonged procedure may not be possible without resulting in significant patient harm (5Permentier K. Vercammen S. Soetaert S. Schellemans C. Carbon dioxide poisoning: a literature review of an often forgotten cause of intoxication in the emergency department.Int J Emerg Med. 2017; 10: 14Crossref PubMed Scopus (73) Google Scholar). In addition, our findings suggest that prefilling the bags with oxygen may obviate the need for continuous oxygen insufflation via additional tubing during use because hypercarbia will limit use in this context long before hypoxia develops. This will have the advantage of simplifying the setup and reducing the risk that an already-vulnerable seal quality may be further compromised by the need to allow for additional inflow tubing. If faced with no alternative but the use of such PPE, we suggest the following: choosing as generously sized a bag as possible without sacrificing functionality, trial runs to assess individual tolerance prior to actual use, and preoxygenation of bag and user and possibly mild hyperventilation prior to donning, to delay the onset of hypoxia and hypercarbia. Where possible, we also suggest having a second operator available to spot and keep time for the first, and to don and take over as a contingency during longer procedures. Capnography monitoring, if available, may be considered, although use must again be weighed against the disadvantages of increasing unwieldiness and complexity of the setup. Risk-mitigation measures notwithstanding, the improvised PPE described above is manifestly inappropriate for all but the most dire of circumstances. Yet, that is the reality confronting many of our colleagues worldwide, who continually inspire us with their courage. We join the call urging that every effort be made to protect the safety of health care providers and patients by ensuring that appropriate PPE is made available where needed. Do-It-Yourself (DIY) Disposable Aerosol BoxJournal of Emergency MedicineVol. 59Issue 4PreviewWe read with great interest an article by Lee et al. on effective use of plastic bags as personal protective equipment during airway management for patients with coronavirus disease 2019 (COVID-19) (1). Safe airway management that minimizes exposure to aerosol from patients with COVID-19 has become a pressing issue for all emergency physicians. Several strategies have been proposed to this end, one of which involves the use of a transparent acrylic “aerosol box” designed to create a barrier to aerosol transmission during intubation, while allowing ample room for medical procedures to be carried out (1–4). Full-Text PDF" @default.
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• W3016231625 title "Plastic Bags as Personal Protective Equipment During the COVID-19 Pandemic: Between the Devil and the Deep Blue Sea" @default.
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